Physical Activity Profile and Sedentary Behaviour in Adults with Cystic Fibrosis

Last updated: March 5, 2025
Sponsor: Hospices Civils de Lyon
Overall Status: Active - Recruiting

Phase

N/A

Condition

Cystic Fibrosis

Lung Disease

Scar Tissue

Treatment

Characterize the physical activity and sedentary lifestyle profile of adults with cystic fibrosis

Clinical Study ID

NCT06507956
69HCL23_1132
2024-A01077-40
  • Ages 18-65
  • All Genders

Study Summary

Cystic fibrosis is a multisystem genetic disease whose severity, linked to the nature of the mutation in the gene carried, is linked to respiratory impairment, which determines the vital prognosis.

Considerable progress has been made in the management of this disease, amplified in recent years by the arrival of CFTR (cystic fibrosis transmembrane conductance regulator) modulator drugs, and in particular the triple treatment combination of elexacaftor-tezacaftor-ivacaftor (ETI). This modulator therapy improves clinical condition, particularly respiratory, and transforms quality of life and prognosis for some patients. Faced with this clinical improvement, practices and care paths are adapting. Professionals will have to cope with the emergence of new clinical conditions linked to the ageing of this at-risk population and the functional decline due to a sedentary lifestyle and age.

The working hypothesis is that a better understanding of the physical activity and sedentary lifestyle profiles of the adult population with cystic fibrosis, and in particular the characterization of the profile of inactive and high sedentary patients under ETI, will enable us to identify and target patients whose lifestyle habits reflect a greater health risk, and for whom care by rehabilitators and adapted physical activity (APA) teachers and personalized advice could be put in place.

The aim of this study is to characterize the physical activity and sedentary profile of adults with cystic fibrosis.

ACTIVMUCO is an observational, cross-sectional, single-center study. A subgroup of adults with high sedentary and inactive under ETI will be studied more specifically by actimetry (prospective follow-up) and interview.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients (male or female) of legal age,

  • Patients with cystic fibrosis (CF) regularly followed at Hôpital Lyon Sud's cysticfibrosis center, who volunteered to take part in the study.

Exclusion

Exclusion Criteria:

  • People who, due to the presence of co-morbidities, do not have motor and cognitiveskills compatible with independent walking or orthostatic physical activity.

  • People whose clinical situation contraindicates the practice of adapted physicalactivity

  • Pregnant women

  • People who do not have the intellectual or linguistic capacity to understand thequestionnaires

  • Persons deprived of their liberty by judicial or administrative decision

  • Persons under psychiatric care

  • Persons admitted to a health or social establishment for purposes other thanresearch

  • Adults under legal protection (guardianship, curatorship).

  • Persons not affiliated to a social security scheme or beneficiaries of a similarscheme

Study Design

Total Participants: 270
Treatment Group(s): 1
Primary Treatment: Characterize the physical activity and sedentary lifestyle profile of adults with cystic fibrosis
Phase:
Study Start date:
September 17, 2024
Estimated Completion Date:
March 03, 2026

Connect with a study center

  • Hôpital Lyon Sud

    Pierre-Bénite, 69310
    France

    Active - Recruiting

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.