Additive Effects of Clonidine Used in Propofol Sedation in Colonoscopy

Last updated: July 20, 2024
Sponsor: Tanta University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Colon Cancer Screening

Anesthesia

Treatment

Propofol combined with clonidine

Propofol

Clinical Study ID

NCT06507410
36264PR725/6/24
  • Ages 18-65
  • All Genders

Study Summary

The objective of this study was to compare safety, satisfaction, and efficiency outcomes of propofol versus propofol with clonidine in patients undergoing colonoscopy.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age 18-65 years.

  • Both sexes.

  • American Society of Anesthesiology (ASA) physical status I-II.

  • Patients undergoing colonoscopy.

Exclusion

Exclusion Criteria:

  • Patients had recent history of colonoscopy.

  • Previous colonic resection.

  • Severe heart failure (ejection fraction < 30%).

  • Known history of hypersensitivity to propofol or clonidine and any need foranesthetic drug administration other than the study protocol.

Study Design

Total Participants: 62
Treatment Group(s): 2
Primary Treatment: Propofol combined with clonidine
Phase:
Study Start date:
July 20, 2024
Estimated Completion Date:
September 01, 2024

Study Description

Colonoscopy is one of the most common procedures in the world, Colonoscopy is a procedure often performed for prevention, diagnosis, and treatment of a variety of symptoms and diseases of the lower digestive tract, and sedation or anesthesia should be considered as an important tool to increase its effectiveness.

Sedation and analgesia are considered key components, as they reduce anxiety and discomfort and therefore improve the procedure tolerability and patient satisfaction, minimize risk of complications and provide better conditions for the examination.

Propofol may be used alone or in combination with opioids and/or benzodiazepines.

The use of propofol alone requires higher doses, which may lead to increased incidence of side effects. However, the risks and benefits of adding analgesic and sedative to propofol are controversial, and the selection of drugs is a crucial factor in determining the outcomes.

Clonidine apparently produces its sedative and anaesthetic-sparing effects by stimulation of centrally located alpha2 adrenoceptors. Analgesia seems to be mediated mainly by activation of alpha2 adrenoceptors in the dorsal horn of the spinal cord.

Connect with a study center

  • Tanta University

    Tanta, El-Gharbia 31527
    Egypt

    Active - Recruiting

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