Genetic and Epigenetic Background of Inner Ear Dysfunction in Turner Syndrome

Last updated: April 25, 2025
Sponsor: Gødstrup Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Turner Syndrome

Severe Short Stature

Ear Infections (Pediatric)

Treatment

N/A

Clinical Study ID

NCT06507007
LHM-TS-2024
  • Ages 18-60
  • Female
  • Accepts Healthy Volunteers

Study Summary

The goal of this case-control study is to pave the way for new revolutionary treatment measures within hearing loss that could either replace or delay the need for hearing aids. The study focuses on people with Turner syndrome (TS).

The aim is to find out if there are specific DNA methylation patterns and/or RNA expression profiles linked to sensorineural hearing loss (SNHL) in people with TS. Additionally, the structure and function of the inner ear in these individuals will be examined to see if there is a connection to their epigenetic profile.

The main question it aims to answer is: Does epigenetics constitute a common denominator for some of the unexplained SNHL cases?

Turner Syndrome (TS) represents an ideal model for studying epigenetics related to sensorineural hearing loss (SNHL).

Participants will undergo the following tests:

  • Ear examinations

  • Hearing tests

  • Balance tests

  • Blood tests

  • MRI scans

  • CBCT (cone-beam computed tomography) scans

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • age between 18 and 60 years old

Exclusion

Exclusion Criteria:

  • Contraindications for the MRI or CBCT

  • Serious medical disorders

  • Neurological or psychiatric disorders of any kind

  • Use of medication that is known to influence inner ear function

  • Medical history with dizziness or hearing problems (controls only)

Study Design

Total Participants: 150
Study Start date:
February 01, 2025
Estimated Completion Date:
July 30, 2027

Connect with a study center

  • ENT department of Gødstrup Hospital

    Herning, 7400
    Denmark

    Active - Recruiting

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.