Effects of Coenzyme Q10 Supplement on Cardiovascular Risk Factors in Subjects at High Risk of Metabolic Syndrome

Inclusion Criteria:

• Metabolic syndrome or high-risk groups with metabolic syndrome are defined assubjects with metabolic syndrome according to the International Diabetes Federation (IDF) Chinese Adult Criteria, and high-risk groups are defined as those who meet atleast two MetS risk factors. The specific criteria are as follows:

1. Aged 30-90 years old;

2. Two or more of following are acceptable:

3. Abdominal obesity (central obesity): waist circumference >=90 cm for men and >=80cm for women;

4. Hyperglycemia: fasting blood glucose ≥ 5.6mmol/L or taking hypoglycemic drugs;

5. Hypertension: systolic blood pressure >=130mmHg and (or) diastolic bloodpressure >=85mmHg or taking blood pressure medications;

6. Fasting TG>=1.70mmol/L or taking antihyperlipidemic drug;

7. Fasting HDL-C<1.04 mmol/L for men, <1.29 mmol/L for women or takingantihyperlipidemic drug; 3) Sign informed consent and insist on participatingin the research.

Exclusion Criteria:

1. Take drugs/dietary supplements, such as aspirin, fish oil and etc., that affectplatelet function in recently six months; 2) blood system disease or infection;
2. Blood pressure >=160/100mmHg; 4) Low platelet count (whole bloodplatelet<100 x 10^9/mL); 5) Abnormal hemoglobin (male <120g/L, female <110g/L);
3. Low hematocrit (male <40%, female <37%); 7) Prothrombin time (PT) is outsidethe normal reference range; 8) Pregnant women or nursing mothers; 9) Abnormalmenstrual cycle, taking birth control pills or hormone replacement therapy; 10)Gastric ulcer, liver or kidney dysfunction.