Quality of Life After Transanal Total Mesorectal Excision Compared to Traditional Total Mesorectal Excision

Last updated: July 9, 2025
Sponsor: Cantonal Hospital of St. Gallen
Overall Status: Completed

Phase

N/A

Condition

Rectal Cancer

Colon Cancer

Surgery

Treatment

Transanal total mesorectal excision

Abdominal total mesorectal excision

Clinical Study ID

NCT06505863
taTME QoL
  • Ages > 18
  • All Genders

Study Summary

The improvement in prognosis of rectal cancer through modern therapy modalities rises questions regarding quality of life (QoL) and functional outcomes. Evidence for long-term QoL and functional outcomes of transanal total mesorectal excision (taTME) is not provided in current literature. This study will compare short-term and long-term QoL and functional outcomes after taTME compared to traditional abdominal TME (laparoscopic, robotic, and open approach)

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • elective total mesorectal excision followed by reconstruction with anastomosis forprimary rectal cancer

Exclusion

Exclusion Criteria:

  • diagnoses other than rectal cancer

  • recurrent rectal cancer

  • partial mesorectal excision

  • discontinuity resection (no anastomosis)

  • incomplete TNM staging information

  • metastatic cancer

  • 30-day mortality

  • lack of quality of life data

  • patient decline

  • age under 18 years

Study Design

Total Participants: 249
Treatment Group(s): 2
Primary Treatment: Transanal total mesorectal excision
Phase:
Study Start date:
August 01, 2024
Estimated Completion Date:
July 01, 2025

Study Description

Quality of life and functional outcomes of patients undergoing taTME or abTME for stage I-III rectal cancer will be analysed. A retrospective propensity score-adjusted analysis of prospectively conducted data will be performed. The primary endpoint QoL will be assessed by the European Organization for Research and Treatment of Cancer core questionnaire (EORTC QLQ-C30). Secondary endpoints are the functional outcomes according to the EORTC QLQ-C30 questionnaire.

Connect with a study center

  • Cantonal Hospital of St.Gallen

    Saint-Gall, 9000
    Switzerland

    Site Not Available

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