Migraine Attack Treatment Response Molecular and Clinical BiOmarkers (MAMBO) Phase I

Phase

N/A

Condition

Migraine (Adult)

Oral Facial Pain

Treatment

Sumatriptan

Clinical Study ID

NCT06503848

EOM(AG)053/2022(6055)

Ages 18-45
All Genders

Study Summary

The goal of this observational study is to identify differential traits in spontaneous migraine attacks that can help us predict the response to treatment with sumatriptan.

Participants will be asked to register the headache characteristics before and after taking sumatriptan and whether the treatment was effective or not during four migraine attacks.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Migraine with or without aura diagnosis according to ICHD-3 criteria
<8 migraine days per month
Be able to read, write and understand instructions.
Have internet access and mail address
Signing of the informed consent

Exclusion

Exclusion Criteria:

Active preventive treatment for migraine
Active medication with an effect over the central nervous system
Serious physical or psychiatric condition
Cardiovascular or hepatic disease
Pregnant or breastfeeding women
Any triptan contraindication
Severe migraine attacks without previous response to triptans or NSAIDs

Study Design

Sumatriptan

January 25, 2024

December 31, 2024

Study Description

There is still an unmet need in acute migraine treatment, some patients don't respond properly to acute medication.

There are some interindividual differences in clinical characteristics of migraine attacks. These differences may determine the response to acute treatment. Describing the phenotypical differences between patients who are responders and patients non-responders will allow us to offer a personalized treatment.

The aim of the study is to determine which characteristics are associated with a response or a non-response to acute treatment with sumatriptan.

Participants will be asked to register the headache characteristics and accompanying symptoms during 4 spontaneous migraine attacks and its response to treatment with sumatriptan.

Connect with a study center

Hospital Universitari Vall d'Hebron
Barcelona,
Spain
Active - Recruiting

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