The Effect of phoSPHocreatine on mEdical Emergency Team (Met) tREated Patients

Inclusion Criteria:

1. Admitted in hospital (but outside ICU)

2. Age>=18 years

3. Written informed consent

4. Serum creatinine <=2 mg/dl

5. Patient with impending or underlying cardiac failure or cardiac arrest,irrespectively of the primitive organ failure, and the Medical Emergency Team (MET)is called upon at least one of the following:

6. Threatened airways;

7. Respiratory arrest;

8. Respiratory rate <5 or >36 breaths per min;

9. Pulse rate <40 or >140 beats per min;

10. Systolic blood pressure < 90 mm Hg;

11. Sudden fall in level of consciousness;

12. Fall in Glasgow coma scale of > 2 points.

Exclusion Criteria:

1. Age < 18 years;

2. Ongoing cardiac massage;

3. Current hospital admission from a care nursing facility;

4. Planned discharge to a care nursing facility;

5. Reasons for withdrawal of life-sustaining therapy;

6. History of kidney transplantation;

7. Solitary kidney (by any reason);

8. Serum Creatinine > 2 mg/dl;

9. Immediate need for ICU admission;

10. Known allergy to PCr;

11. Pregnancy;

12. Previous enrollment and randomization into this trial;

13. Administration of PCr in the previous 30 day.