Bilateral Subthalamic Stimulation in PD Patients With Impulse Control Disorders - STIMPulseControl

Inclusion Criteria:

1. Age at the time of enrollment: ≤ 70 years

2. Duration of idiopathic Parkinson's disease ≥ 4 years diagnosis of PD acc. MDSclinical diagnostic criteria

3. Moderate or severe impulse control disorder or related behavioral disordersaccording to Ardouin, with at least 1 score greater than or equal to 3 (or at least 2 scores greater than or equal to 2) on the Ardouin behaviour scale with thefollowing items considered to reflect ICBDs or related behaviors: pathologicalgambling, hypersexuality, shopping, eating, hobbyism, punding and compulsivemedication use

4. MDS-UPDRS III improvement of ≥ 30% in the standardized levodopa test

5. MoCA ≥ 24 in the meds on condition

6. BDI-II score < 20 in the meds on condition, or Patients with moderately severedepression with a BDI-II between 20 and 28 points, strict consideration must be madewith the involvement of a psychiatrist. Patients must be willing and able to complythis.

7. Patients able to understand the study requirements and the treatment procedures

8. Written informed consent before any study-specific tests or procedures are performed

Exclusion Criteria:

9. Surgical contraindications to undergo DBS operation

10. Ongoing severe depression (BDI-II > 28) or depression of any severity with suicidalideation item 9 of BDI-II > 1

11. Dementia (MoCA < 24) in the meds on condition

12. Any prior movement disorder treatments that involved intracranial surgery/ablationor intracranial device implantation

13. Any other active implanted device that is likely to interfere with the implantationor functioning of the DBS system

14. Simultaneous participation in another clinical trial targeting or potentiallyinterfering with ICD

15. Any history of recurrent seizures or haemorrhagic stroke

16. Fertile women not using adequate contraceptive methods

17. Any terminal illness with significantly reduced life expectancy which exclude DBSimplantation according to standard clinical care

18. A female who is breastfeeding or of child-bearing potential with a positive urinepregnancy test or not using adequate contraception

19. Any impairment that would limit subject's ability to participate in the study andperform study procedures

20. Have any significant medical condition that is likely to interfere with studyprocedures or likely to confound evaluation of study endpoints