Effectiveness of EMDR in Borderline Personality Disorder

Last updated: February 23, 2026
Sponsor: Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Overall Status: Active - Recruiting

Phase

N/A

Condition

Schizotypal Personality Disorder (Spd)

Borderline Personality Disorder

Mood Disorders

Treatment

Trauma focused psychotherapy: EMDR

Clinical Study ID

NCT06493708
EMDR2023-02
  • Ages 18-65
  • All Genders

Study Summary

Borderline personality disorder (BPD) is a severe mental disorder characterized by four major symptomatological domains: interpersonal instability, perceptive and identity disorders, emotional and behavioural dysregulation. Considering a multifactorial etiological model, it has been suggested that the interaction between behavioral, environmental and genetic factors may promote the development of BPD. Early life stress events (ELS) in childhood and adolescence are highly prevalent in this population and constitute an environmental risk factor for the development of BPD. This correlates with the fact that Post-traumatic Stress Disorder (PTSD) is frequently comorbid in BPD leading to more severe symptoms and worse psychosocial functioning. At the therapeutic level, the treatment of BPD is an open challenge as psychotherapeutic interventions are of limited effectiveness and characterized by high drop-out rates. Eye Movement Desensitization and Reprocessing (EMDR) is the gold standard for treating PTSD. However, scientific evidence on the application of EMDR in patients with BPD is limited. This study aims to assess the feasibility and effectiveness of an EMDR protocol on the nuclear symptomatology of BPD (emotional and behavioral dysregulation) in a group of DBP patients with/without PTSD comorbidity, through a systematic assessment of the peculiar dimensions of the disorder. The basic hypothesis is that EMDR, through a short-term intervention, can act both on the traumatic PTSD-like experiences reported by patients and on the clinical manifestations peculiar to DBP, in particular by improving the emotional regulation capacity of patients with BPD.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients must be over 18 years old

  • A current diagnosis of PBD according to the DSM-5 was confirmed using the SCID-5-CVand SCID-5-PD diagnostic scale

Exclusion

Exclusion Criteria:

  • Suicidal ideation in the last 3 months (suicidal thoughts active intentionally butwithout specific planning or suicidal thoughts active with planning andintentionality)

  • Intellectual disability

  • Any active disturbance from use of substances or alcohol

  • Any other diagnosis of Axis I, except for Depressive Disorders, Anxious SpectrumDisorders, Obsessive-Compulsive Disorder.

Study Design

Total Participants: 56
Treatment Group(s): 1
Primary Treatment: Trauma focused psychotherapy: EMDR
Phase:
Study Start date:
October 01, 2024
Estimated Completion Date:
October 01, 2026

Connect with a study center

  • ASST Spedali Civili Brescia

    Brescia 3181554, Brescia 25123
    Italy

    Active - Recruiting

  • ASST Spedali Civili Brescia

    Brescia, 25123
    Italy

    Site Not Available

Map preview placeholder

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.