Biometric Changes After Intervention of Anterior Chamber Angle : an Observational Study

Last updated: July 1, 2024
Sponsor: Zhongshan Ophthalmic Center, Sun Yat-sen University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Glaucoma

Treatment

various types of angle interventions

Clinical Study ID

NCT06492538
2023KYPJ304
  • Ages 30-85
  • All Genders

Study Summary

The drainage angle in the anterior chamber of the eye mediates the outflow of aqueous humor, and pathological changes here can lead to high intraocular pressure and glaucoma. Minimally invasive glaucoma surgery, particularly angle surgery, has advanced recently, allowing clear visualization of angle structures like the trabecular meshwork and Schlemm's canal using surgical goniolens. Techniques for angle intervention include widening the angle, reopening closed angles, and rebuilding outflow pathways using methods such as laser peripheral iridotomy, Argon laser peripheral iridoplasty, and mechanical separation of adhered tissues. Our research team plans to conduct imaging studies to track the healing of angle tissues post-surgery, aiming to support innovation and standardization of minimally invasive angle surgery.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Glaucoma patients eligible for standalone or combined angle intervention surgeries,such as LPI, LPIP, goniosynechialysis, trabeculotomy alone or combined with surgicaliridectomy or phacoemulsification and intraocular lens implantation;

  • Patients capable of undergoing preoperative examinations including CASIA2-OCT (anterior segment OCT), UBM, slit-lamp gonioscopy, IOL Master (or other opticalbiometry);

  • Patients willing to participate in this study, signing informed consent, andagreeing to follow-up according to the study protocol.

Exclusion

Exclusion Criteria:

  • Patients with severe ocular conditions such as corneal infection, ulcer, trauma,ocular tumors, retinal vascular occlusion, and retinal detachment;

  • Those with various types of eye diseases that affect ocular parameter acquisition orinterfere with visual field examination;

  • Long-term local or systemic use of glucocorticoids;

  • Patients with severe systemic diseases;

  • Pregnant or lactating women;

  • Unable to complete 12-month postoperative follow-up.

Study Design

Total Participants: 300
Treatment Group(s): 1
Primary Treatment: various types of angle interventions
Phase:
Study Start date:
December 01, 2023
Estimated Completion Date:
December 30, 2025

Study Description

Pathological elevated intraocular pressure is one of the most important disease characteristics of glaucoma. Blockage of aqueous humor outflow within the eye is the primary cause of high intraocular pressure. The drainage angle in the anterior chamber of the eye mediates the outflow of aqueous humor. Pathological changes in this area can lead to the development of high intraocular pressure and glaucoma, such as primary angle closure glaucoma (PACG) caused by angle closure. Minimally invasive glaucoma surgery has rapidly developed in recent years, with angle surgery being a major branch. With the use of surgical goniolens, structures within the angle, such as trabecular meshwork and Schlemm's canal, can be visualized clearly during surgery. Methods for angle intervention include but not limit ed to widening the peripheral anterior chamber angle, reopening adhered or appositionally closed angles, and rebuilt outflow pathways by incising diseased areas to increase aqueous humor outflow. Techniques include laser peripheral iridotomy (LPI) to relieve pupillary block and deepen the peripheral anterior chamber, Argon laser peripheral iridoplasty (ALPIP) to stimulate iris contraction and widen the angle, and mechanical separation of adhered angle tissues using instruments like goniosynechialysis hooks or iris repositors. Surgical incision using instruments such as Microhook, trabeculectomy hooks, or cannulas can be performed to remove the diseased inner wall of Schlemm's canal and the diseased trabecular meshwork either partially or circumferentially. However, the healing and outcomes of angle tissues following invasive angle interventions, and their impact on surgical outcomes, remain unclear. Therefore, our research team proposes to conduct imaging observation studies to track, observe, and quantify the status of the angle, exploring the healing process of angle tissues. This aims to provide theoretical support for the innovation and standardization of minimally invasive angle surgery.

Connect with a study center

  • Zhongshan ophthalmic center

    Guangzhou, Guangdong 51006dddddd0
    China

    Active - Recruiting

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.