Regular Use of aPDT in the Management and Prevention of Periodontitis Symptoms in Diabetic Patients

Last updated: August 5, 2025
Sponsor: Wellbeing Services County of Pirkanmaa
Overall Status: Active - Recruiting

Phase

N/A

Condition

Diabetes Mellitus, Type 2

Diabetes And Hypertension

Diabetes (Pediatric)

Treatment

Lumoral Treatment

Standard oral hygiene

Clinical Study ID

NCT06486012
R24021L
  • Ages > 18
  • All Genders

Study Summary

This is an investigator-initiated clinical study to establish easy referral and access for diabetic patients from primary health care to oral health care facilities for preventive oral care, periodontal assessment, and treatment, and to investigate the impact of regular home use of aPDT medical device on plaque control and gingival health, when used as an adjunct treatment to standard oral hygiene, and the effect on diabetes control in patients with the risk of periodontal disease, compared to a standard home care oral hygiene regimen.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Diabetic patient treated at community health care;

  • At least 18 years old;

  • Presence of ≥20 teeth;

  • Agreement to participate in the study, and to sign a written consent form;

  • Ability to cooperate with the treatment protocol according to coordinatorinvestigator's assessment.

Exclusion

Exclusion Criteria:

  • Oral thrush;

  • Known sensitivity to near-infrared or antibacterial blue light.

Study Design

Total Participants: 150
Treatment Group(s): 2
Primary Treatment: Lumoral Treatment
Phase:
Study Start date:
January 23, 2025
Estimated Completion Date:
December 31, 2028

Study Description

In earlier studies, a bi-directional link between diabetes and periodontitis has been established: high glucose levels increase the risk of periodontitis while glycemic control is likely to worsen with untreated periodontitis. The treatment of diabetic patients should include easy access from diabetes clinics to oral health care facilities to reduce the potential risks of periodontal disease, or deterioration of existing symptoms of periodontal disease. As part of a holistic approach to healthcare and its resources, more attention needs to be paid to the early detection, and prevention of oral diseases in diabetic patients. Novel testing and treatment methods can play a key role, and a good collaboration between diabetes and oral health care facilities is essential.

The aMMP-8 test can be used to assess the risk of periodontal disease. If the test is positive, latent MMP-8 is activated, so the inflammatory cascade is activated and provides real-time information. The test can also be used to monitor the success of the treatment outcome and can be used to determine the interval between maintenance treatments. In addition, patients' oral self-care should be improved, as most of the work in preventing oral diseases is done at home. The home use of photodynamic dual light therapy (aPDT) can provide additional benefits and also engage patients not only in self-care but also in the whole treatment process. Preliminary studies show that aPDT improves the treatment and maintenance outcomes, and potentially reduces the risk of periodontal disease in addition to self-care.

The combination of easy access to treatment could have wide benefits individually, and also at the community level, including the possibility of building a cost-effective preventive care pathway for patients with prediabetes, type 2 diabetes, and periodontitis, and identifying the risks of both diseases and treating already detected diseases early and in a timely manner.

Connect with a study center

  • Wellbeing Services of County Pirkanmaa

    Tampere, Pirkanmaa 33520
    Finland

    Active - Recruiting

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