Can the Origin of Sperm Affect Embryo Ploidy in Patients with Severe Male Factor Infertility?

Last updated: September 22, 2024
Sponsor: Ganin Fertility Center
Overall Status: Active - Recruiting

Phase

N/A

Condition

Infertility

Men's Health

Hypogonadism

Treatment

Testicular sperm extraction (TESE)

Ejaculate

Clinical Study ID

NCT06476379
GFC-009
  • All Genders

Study Summary

There is evidence indicating that sperm plays a role in determining blastocyst ploidy status. In our study, we aim to compare the outcomes of preimplantation genetic testing for aneuploidy (PGT-A) and the subsequent clinical outcomes following transfers of euploid embryos. This comparison will be conducted between cases where ejaculated sperm and cases where testicular sperm were used for intracytoplasmic sperm injection (ICSI), specifically focusing on severe male factor infertility patients.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Cases planned to have ICSI PGT-A cycles

  • Males diagnosed as severe male factor infertility

  • Normo responder female partners

Exclusion

Exclusion Criteria:

  • Leukocytospermia

  • Presence of varicocele.

  • Known genetic abnormality

  • Use of sperm or oocyte donors

  • Use of gestational carrier

  • Presence of any of the endometrial factors that affect embryo implantation such ashydrosalpings, adenomyosis or previous uterine infection

  • Any contradictions to undergoing in vitro fertilization or gonadotropin stimulation

Study Design

Total Participants: 200
Treatment Group(s): 2
Primary Treatment: Testicular sperm extraction (TESE)
Phase:
Study Start date:
June 25, 2024
Estimated Completion Date:
June 30, 2025

Connect with a study center

  • Ganin Fertility Center

    Cairo, Maadi 11728
    Egypt

    Active - Recruiting

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