Predicting Responses to Exhausting, Prolonged, and Repeated Exercise Demands (PREPARED) for Heat

Last updated: December 17, 2024
Sponsor: State University of New York at Buffalo
Overall Status: Active - Recruiting

Phase

N/A

Condition

Fever

Treatment

20/12 work/rest cycle

40/30 work/rest cycle

30/30 work/rest cycle

Clinical Study ID

NCT06475339
STUDY00007981
CDMRP-BA230031
  • Ages 18-39
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The overall goal of this project is to identify a work/rest cycle that allows for faster mission completion needed in emergency situations, compared to current Army heat guidance, while mitigating heat strain and neuromuscular fatigue. This project will determine the trade-off between faster mission completion and risk of heat strain and physical performance decrements. Completion of this project will allow military leaders to make informed decisions by understanding the impact of their choices on the magnitude of physical performance decrements and expected heat casualties, setting up hot weather missions for success.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Healthy individuals

  • Physically active

Exclusion

Exclusion Criteria:

  • History of cardiovascular, metabolic (such as clinical thyroid disease),respiratory, neural, or renal disease

  • Hypertensive (systolic blood pressure > 139 mmHg, diastolic blood pressure > 89mmHg) or tachycardic (heart rate > 100 bpm) during the screening visit

  • Taking medications or supplements known to effect physiologic responses to exerciseor thermoregulation (e.g., beta blockers, omega-3 fatty acids, statins, aspirin)

  • Tobacco or nicotine use currently or in the past six months

  • Musculoskeletal injury expected to impact exercise in the protocol

  • A positive pregnancy test at any point in the study

  • Study physician discretion based on any other medical condition or medication

  • Inability to understand or follow instructions or the protocol

  • Gastrointestinal disease or previous surgery prohibiting core temperature capsuleuse. Participants with a contraindication can opt to insert the pill rectally as asuppository.

Study Design

Total Participants: 24
Treatment Group(s): 4
Primary Treatment: 20/12 work/rest cycle
Phase:
Study Start date:
November 01, 2024
Estimated Completion Date:
March 31, 2027

Connect with a study center

  • Center for Research and Education in Special Environments

    Buffalo, New York 14214
    United States

    Active - Recruiting

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