68Ga-JH04 PET/CT in Patients With Various Types of Cancer

Last updated: June 7, 2024
Sponsor: First Affiliated Hospital of Fujian Medical University
Overall Status: Active - Recruiting

Phase

1

Condition

Carcinoma

Cancer

Treatment

68Ga-JH04

68Ga-FAPI/18F-FDG

Clinical Study ID

NCT06455735
FirstAHFujian-68Ga-JH04 PET/CT
  • Ages 18-80
  • All Genders

Study Summary

As a novel radiotracer targeting fibroblast activation protein (FAP), 68Ga-JH04 is promising as an excellent imaging agent for various cancers. In this study, we observed the diagnostic performance of 68Ga-JH04 PET/CT in patients with different types of cancer, and compared its imaging results with those of 68Ga-FAPI or 18F-FDG PET/CT.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Various solid tumors with available histopathological findings Signed informed consent

Exclusion

Exclusion Criteria:

pregnant or lactational women who suffered from severe hepatic and renal insufficiency

Study Design

Total Participants: 30
Treatment Group(s): 2
Primary Treatment: 68Ga-JH04
Phase: 1
Study Start date:
March 01, 2024
Estimated Completion Date:
April 01, 2026

Study Description

Carcinoma-associated fibroblasts (CAFs) are an integral part of the tumor microenvironment, and fibroblast activation protein (FAP), as a specific marker of CAFs, is overexpressed in more than 90% of epithelial malignant tumors' CAFs, with limited expression in normal tissues, making it an appropriate target for various tumors. Currently, several tracers targeting FAP for diagnostic purposes have been developed, such as 68Ga-FAPI-04, 68Ga-FAPI-02, showing high efficacy in tumor staging and restaging. As an emerging molecule targeting FAP, 68Ga-JH04, in this study, the diagnostic performance of 68Ga-JH04 PET/CT in patients with different types of cancer were observed. Its imaging results were compared with those of 68Ga-FAPI or 18F-FDG PET/CT.

Connect with a study center

  • The First Affiliated Hospital of Fujian Medical University

    Fuzhou, Fujian 350000
    China

    Active - Recruiting

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