Epidural Electrical Stimulation for Spinal Cord Injury Patients and Corticospinal Motor Circuit Improvement

Last updated: September 16, 2025
Sponsor: Buddhist Tzu Chi General Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Spinal Cord Injuries

Treatment

Epidural Stimulator

Clinical Study ID

NCT06455137
IRB112-067-A
  • Ages 20-70
  • All Genders

Study Summary

The study aims to examine the plausible interventional mechanisms underlying the effects of epidural spinal cord stimulation.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • SCI ASIA: A, B, C,D

  • Between 20 and 70 year of age

  • >1 year post SCI

  • Complete or incomplete spinal cord injury.

  • Expected will undergo spinal cord stimulation surgery.

  • Continued rehabilitation after surgery for spinal cord injury.

  • Able to comply with procedures and follow up.

  • Stable medical condition without cardiopulmonary disease or dysautonomia that would

  • contraindicate participation in lower extremity rehabilitation or testingactivities

Exclusion

Exclusion Criteria:

  • Have significant cognitive impairment (MMSE<24).

  • Had a mental illness within one year or been treated in the past.

  • Have Major depressive disorder.

  • Active cancer diagnosis.

  • Painful musculoskeletal dysfunction, unhealed fracture, contracture, pressure sore,or urinary tract infection that might interfere with stand or step training.

  • Cardiovascular or musculoskeletal disease or injury that would prevent fullparticipation in physical therapy intervention.

  • Unable to read and/or comprehend the consent form.

  • Have concerns about this trial and do not sign consent.

Study Design

Total Participants: 20
Treatment Group(s): 1
Primary Treatment: Epidural Stimulator
Phase:
Study Start date:
April 30, 2024
Estimated Completion Date:
December 31, 2026

Study Description

The purpose of this study is for the treatment of spinal cord injury (SCI) paralysis patients use the signal by electrophysiological analysis of epidural spinal cord stimulation (SCS) settings that promote limbs activity so that SCI patients can restore motor ability under multiple sensory stimuli and multimodal electrical stimulation rehabilitation. The investigators hope to establish an atresia nerve regulation strategy and observe that the original blocked neural circuits can improve nerve plasticity by SCS. Even can establish new connections through residual nerves and allow SCI patients to rebuild neural circuits without SCS to restore limbs mobility and improve quality of life.

Connect with a study center

  • Buddhist Tzu Chi Medical Foundation Hualien Tzu Chi Hospital

    Hualien City, 970
    Taiwan

    Site Not Available

  • Buddhist Tzu Chi Medical Foundation Hualien Tzu Chi Hospital

    Hualien City 1674504, 970
    Taiwan

    Active - Recruiting

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