Impact of Regular Consumption of Eggs and Nutrients Fortified Eggs on Eczema Condition in Singapore Individuals

Last updated: July 17, 2024
Sponsor: National University of Singapore
Overall Status: Active - Recruiting

Phase

N/A

Condition

Aging

Dermatitis, Atopic

Allergy

Treatment

Regular egg with habitual diet

Nutrient-fortified egg

Clinical Study ID

NCT06454942
S26
  • Ages 21-59
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The study aims to assess the effects of daily consumption of nutrients-fortified eggs on eczema condition in Singapore individuals with eczema. The investigators hypothesize that egg consumption will improve eczema condition and nutrients fortified egg consumption will improve further improvements when compared to standard egg consumption in individuals with eczema

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. English-literate and able to give informed consent in English

  2. Male and female participants, aged between 21 and 59 inclusive

  3. Healthy individuals with no underlying condition or on regular medication

  4. BMI between 18.5-25 kg/m2

  5. Mild to moderate severity of eczema, which will also be determined using ourquestionnaires during the screening visit

Exclusion

Exclusion Criteria:

  1. Significant change in body weight (3 kg or more) in the past 3 months

  2. Significant exercise pattern over the past 3 months defined as high-intensityexercise of more than 3 hours per week

  3. Known food allergy to eggs

  4. Taking dietary supplements which may impact the study results

  5. Having gastrointestinal disorders not suitable for the study

  6. Current smokers

  7. Consumes more than 2 alcoholic drinks per day i.e. one drink is defined as either 150ml of wine, 340ml of beer/cider, or 45ml of distilled spirit

  8. Taking lipid-lowering and blood pressure-controlling medications for less than 3years

  9. Pregnant or lactating women, or planning to conceive in the next 6 months

  10. Unwilling to stop the medication of eczema during the study, either topical creamsor oral medications

  11. Hierarchical link (professional and familial ties) with the research team members

  12. Participating in another clinical study

  13. Having blindness in one eye or more, eye diseases, retinal/lens/optical nervesurgery, or other eye conditions that may impact the study results

  14. Low-quality macular pigment optical density results were determined during thescreening visit.

Study Design

Total Participants: 44
Treatment Group(s): 2
Primary Treatment: Regular egg with habitual diet
Phase:
Study Start date:
July 17, 2024
Estimated Completion Date:
May 31, 2026

Study Description

This is a double-blind, randomized, parallel study and all subjects will complete a 12-week study period. Subjects will be tasked to consume nutrients-fortified eggs and regular eggs daily for 12 weeks. After which, subjects are assessed for changes in carotenoid status, antioxidant and anti-inflammatory biomarkers, skin and eye health measurements, and other biomarkers of health.

Connect with a study center

  • Department of Food Science and Techonology, Block S13

    Singapore, 117550
    Singapore

    Active - Recruiting

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