Amygdala and dLPFC MRI-TIS for Depression in Adolescents

Inclusion Criteria:

• Participants must be aged between 14 and 18, with no gender restrictions;

• A diagnosis of depression made by the study physician based on the Diagnostic andStatistical Manual of Mental Disorders (DSM-5);

• HAMD-17 score of 17 or higher;

• Participants must not have changed their antidepressant medication regimen from 30days prior to signing the informed consent form through the duration of theexperiment;

• Eligible individuals or their authorized representatives must demonstrate, asassessed by the study physician, a comprehensive understanding of the study'sobjectives and procedures, be capable of adhering to the requirements set forth inthe study protocol, and provide their signature on the informed consent form.

Exclusion Criteria:

• Eligible participants must not have a history of psychiatric or neurologicaldisorders, as judged by the investigator, which may impact the evaluation of thestudy's efficacy;

• Participants must not have a history of seizures or prior episodes of epilepsy;

• The presence of metallic foreign objects within the cranial structure or metalliccardiac implants;

• Participants must not have a diagnosis of organic brain disease, nor a history ofsignificant cranial trauma or neurosurgical intervention;

• Participants received electroconvulsive therapy or other physical therapies (such astranscranial magnetic stimulation therapy); The researcher evaluated theindividual's mental state and determined it to present a significant risk ofsuicidal ideation or behavior;

• Pregnant or breastfeeding;

• Participants who are concurrently engaged in other clinical interventional trials;

• Participants presenting with other circumstances that the investigator deemsunsuitable for the intervention being studied