FET-PET/MRI Based Treatment Planning for Glioblastoma Multiforme in Post-Surgical Patients (FET-TREAT)

Last updated: June 26, 2024
Sponsor: Sunnybrook Health Sciences Centre
Overall Status: Active - Recruiting

Phase

N/A

Condition

Astrocytoma

Glioblastoma Multiforme

Gliomas

Treatment

FET-PET/MRI

Clinical Study ID

NCT06451042
5919
  • Ages > 18
  • All Genders

Study Summary

Glioblastoma multiforme (GBM) represent the most common primary brain malignancy and prognosis remains poor. The most common subtype is glioblastoma which has a 5-year survival rate of approximately 5%. Despite advances in MRI techniques, accurately determining total extent of tumor remains a challenge. The result is incomplete treatment resulting in reduced survival or overtreatment resulting in avoidable treatment related morbidity. A more accurate means of assessing tumor extent is needed to guide management to improve patient survival and quality of life.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Each participant must meet all of the following inclusion criteria to participate in this study:

  • ≥ 18 years of age

  • Diagnosis of glioblastoma multiforme

  • Post-maximally safe surgical resection

  • No prior radiation or systemic treatment for high grade glioma

  • Able to tolerate PET/MRI scan with intravenous contrast

  • Willing to provide informed consent

Exclusion

Exclusion Criteria:

All participants meeting any of the following exclusion criteria at baseline screening will be excluded from participation in this study:

  • MRI contraindication

  • Creatinine clearance < 30mL/min

  • Inability to lie still for 60 minutes

  • Gadolinium allergy

  • Positive pregnancy test

  • Breastfeeding

  • Patient unable to follow the protocol for any reason

Study Design

Total Participants: 15
Treatment Group(s): 1
Primary Treatment: FET-PET/MRI
Phase:
Study Start date:
July 01, 2024
Estimated Completion Date:
May 31, 2026

Connect with a study center

  • Sunnybrook Health Sciences Centre

    Toronto, Ontario M4N 3M5
    Canada

    Active - Recruiting

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