Study of Danicopan as Add-on Treatment to Ravulizumab or Eculizumab in Pediatric Participants With PNH Who Have Clinically Significant Extravascular Hemolysis

Last updated: June 30, 2025
Sponsor: Alexion Pharmaceuticals, Inc.
Overall Status: Active - Recruiting

Phase

3

Condition

Bone Marrow Disorder

Anemia

Aplastic Anemia

Treatment

Danicopan

Clinical Study ID

NCT06449001
D7332C00006
ALXN2040-PNH-302
  • Ages 12-17
  • All Genders

Study Summary

The primary objective of this study is to evaluate efficacy of danicopan as add-on treatment to ravulizumab or eculizumab as assessed by hemoglobin (Hgb) change from Baseline at Week 12 in pediatric participants with paroxysmal nocturnal hemoglobinuria (PNH) and clinically significant extravascular hemolysis (CS-EVH).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Confirmed diagnosis of PNH.

  • CS-EVH defined by: Anemia: Hgb ≤ 10.5 g/dL, and absolute reticulocyte count ≥ 100 × 109/L

  • Treated with ravulizumab or eculizumab for at least 12 weeks immediately precedingDay 1, the dose received should be stable during this period, and there should be noanticipated changes in dosage or interval during the first 12 weeks of this study.

  • all participants must be vaccinated against meningococcal infection from serogroupsA, C, W, and Y and serogroup B within 3 years prior to, or at least 14 days prior toDay 1

  • vaccinated against Haemophilus influenzae type b (Hib) and Streptococcus pneumoniae

Exclusion

Exclusion Criteria:

  • Platelet count < 30000/μL or there is a need for platelet transfusions.

  • ANC < 500/μL.

  • Clinically significant laboratory abnormalities related to liver function,including:

  • ALT > 2 × ULN or ALT > 3 × ULN for participants with documented liver ironoverload defined by serum ferritin values ≥ 500 ng/mL.

  • Direct bilirubin > 2 × ULN, unless, in the Investigator's opinion, is due tohemolysis or Gilbert's syndrome based on medical history.

  • Current evidence of biliary cholestasis.

  • Known aplastic anemia or other bone marrow failure that requires HSCT or othertherapies, including anti-thymocyte globulin and immunosuppressants unless thedosage of immunosuppressant has been stable for at least 12 weeks before Day 1 andis expected to remain stable through Week 12.

  • History of a major organ transplant (eg, heart, lung, kidney, liver) or HSCT.

  • Known or suspected complement deficiency.

  • Active bacterial or viral infection, a body temperature > 38°C on 2 consecutivedaily measures, evidence of other infection, or history of any febrile illnesswithin 14 days prior to first study intervention administration.

Study Design

Total Participants: 6
Treatment Group(s): 1
Primary Treatment: Danicopan
Phase: 3
Study Start date:
September 30, 2025
Estimated Completion Date:
July 31, 2028

Connect with a study center

  • Research Site

    Paris, 77019
    France

    Active - Recruiting

  • Research Site

    Leeds, LS9 7TF
    United Kingdom

    Site Not Available

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