OsteoGen Plug vs. Freeze-dried Bone Allograft With Collagen Barrier

Inclusion Criteria:

• Subjects 18 to 75-yrs of age.

• Subjects with a nonterminal premolar in need of extraction with intention to pursueimplant replacement.

• Proposed treatment site must have intact buccal cortical plates > 1 mm in thickness (buccal bone dehiscence up to 25% root length is permissible). Apical lesions areacceptable which do not perforate the cortical plate).

• Proposed treatment site must have intact adjacent natural teeth. (no adjacentedentulous sites or implants).

• Subjects can provide self-care (oral hygiene) without disabilities requiringassistance with daily oral hygiene measures.

• Subjects will have read, understood, and signed an institutional review board (IRB)approved Informed Consent Form (ICF).

• Subjects must be able and willing to follow study procedures and instructions.

Exclusion Criteria:

• Subjects with reported allergy or hypersensitivity to any of the products to be usedin the study.

• Subjects with untreated / active periodontal disease.

• Subjects with vesiculobullous processes or other similar chronic oral lesions /conditions resulting in gingival irritation, discomfort/pain, or erosions.

• Tobacco/Cannabis users including cigarettes, vape, cigars, or smokeless tobacco.

• Uncontrolled medical conditions (e.g., diabetes mellitus, hypertension, cancer)

• Subjects who are lactating or pregnant or planning to become pregnant through theirprojected study duration.

• Subjects who would require a tissue supported interim prosthesis i.e. acrylic /valplast RPD (tooth supported interim prostheses i.e. essix retainers areacceptable)

• Subjects with long-term history of oral bisphosphonates (> 10 years).

• Subjects with a history of intravenous bisphosphonates.

• Subjects taking medications known to affect gingival conditions. (e.g., hyperplasia)

• Subjects taking corticosteroids or immunosuppressants on a regular basis prior tobaseline examination.

• Subjects taking anticoagulant medications such as warfarin or Plavix or Eliquis whoare not medically cleared to hold medication prior to and during procedure.

• Subjects participating in other clinical studies involving therapeutic intervention (either medical or dental).

• Subjects, who in the opinion of the investigator, for any reason other than thoselisted above, will not be able to complete the study per protocol.