Transient Receptor Potential Channels

Last updated: January 15, 2025
Sponsor: Penn State University
Overall Status: Active - Recruiting

Phase

1

Condition

Aging

Treatment

Vehicle gel

TRPV4 Agonist

TRPM8 Agonist

Clinical Study ID

NCT06444594
24921
  • Ages 18-85
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Neurovascular signaling in the skin associated with stimulation of the transient receptor potential (TRP) channels. These channels are stimulated by both temperature and naturally occurring bioactive agents found in mint, chili peppers, garlic, etc. The aim of the study is to examine how topically applied TRP channel agonists including menthol, capsaicin and camphor impact neurovascular responses in the skin.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • 18-85 years old.

  • Women will not be pregnant and/or breastfeeding.

Exclusion

Exclusion Criteria:

  • Currently pregnant or breastfeeding

  • Nicotine use (e.g., smoking, chewing tobacco etc.), quantified as more than 100cigarettes or cigars in a lifetime)

  • Known skin allergies or current rash, skin disease, disorders of pigmentation

  • Diabetes

  • Body mass index >35kg*m-2

  • Using calcium channel blockers

  • Raynaud's syndrome

  • Allergy or hypersensitivity to menthol, camphor, capsaicin or adhesive

  • Regular use (defined as greater than once a week) of topical analgesics that containmenthol, camphor or capsaicin

Study Design

Total Participants: 45
Treatment Group(s): 5
Primary Treatment: Vehicle gel
Phase: 1
Study Start date:
July 17, 2024
Estimated Completion Date:
December 31, 2026

Connect with a study center

  • Noll Laboratory

    University Park, Pennsylvania 16802
    United States

    Active - Recruiting

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