Orexin Receptor Antagonism and Sleep in Stimulant Use Disorder

Inclusion Criteria:

• Meet Diagnostic and Statistical Manual of Mental Disorders(DSM-5)criteria forprimary stimulant use disorder (either cocaine or methamphetamine)

• Be fluent in English and able to understand the consent form

Exclusion Criteria:

• Have an opioid use disorder of any severity

• Have a greater than moderate substance use disorder on any other substance

• Undergoing medication-assisted treatment for withdrawal of any substance

• Have any medical conditions contraindicating SUVO (e.g., severe pulmonary disease,severe cardiovascular disease or clinically abnormal ECG, severe liver or kidneydisease, seizure disorder, or sleep disorder -particularly narcolepsy)

• Are currently taking medications with known drug interactions with SUVO (e.g.,Monoamine oxidase (MAO) inhibitors, anticonvulsants, haloperidol, phenothiazines,anesthetics, and any sedative)

• Are pregnant or breast feeding

• BMI > 30 (women only)

• Have a current DSM-5 psychiatric disorder or neurological disease requiring on-goingtreatment that would make participation unsafe

• Have history of seizure disorder

• Have a head injury with loss of consciousness in the last 5 years