History of Polycystic Ovary Syndrome in First-degree Relatives

Last updated: November 16, 2024
Sponsor: Etlik Zubeyde Hanım Women's Health Care, Training and Research Hospital
Overall Status: Completed

Phase

N/A

Condition

Reproductive Health

Polycystic Ovarian Syndrome

Treatment

spermiogram test

Clinical Study ID

NCT06442228
2024/05
  • Ages 18-40
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The aim of this study was to investigate the semen analysis results of male patients with first-degree relatives meeting the diagnostic criteria for PCOS.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • The study will include male partners between the ages of 18-40 who have no knowndisease, who give spermiogram test for the evaluation of infertile couple in ourhospital and who have accepted the consent form verbally and in writing.

Exclusion

Exclusion Criteria:

  • Exclusion criteria;

  1. History of any chronic disease, urinary tract or reproductive disease,neurological or psychiatric condition in the male patient and recent fever (≥38°C in the last 3 months)

  2. Those with a history of vasectomy, cryptorchism, radiation history,chemotherapy, infections, sexual dysfunction and endocrine hypogonadism

  3. Especially those with a history of finasteride and dutasteride drug use.

Study Design

Total Participants: 50
Treatment Group(s): 1
Primary Treatment: spermiogram test
Phase:
Study Start date:
October 07, 2024
Estimated Completion Date:
November 16, 2024

Study Description

Polycystic ovary syndrome (PCOS) is an endocrine metabolic disorder characterised by menstrual irregularity, anovulation, clinical and/or biochemical signs of hyper androgenism (hirsutism and/or acne), micropolycystic ovaries and metabolic abnormalities.

This syndrome is clustered in family members and appears to be inherited through an oligogenic mechanism (1,2). As a result of familial clustering of the PCOS phenotype, metabolic risks have been shown to increase in family members, independent of gender.

The presence of a genetic background in the etiopathogenesis of PCOS means that men may also have signs and symptoms equivalent to PCOS. In addition, the genes responsible for PCOS susceptibility in women are also transferred to male relatives of these individuals. Hormonal and metabolic abnormalities have been identified in male relatives of women with PCOS. These men have shown a higher prevalence of early-onset (<35 years) androgenetic alopecia (AGA), type 2 DM and cardivascular diseases. In addition, prostate cancer, benign prostatic hyperplasia (BPH) and prostatitis have also been defined more frequently in this group of individuals (1,3).

In addition, differences in responses to gonadotropin-releasing hormone (GnRH) and FSH and LH levels were found in the brothers of women with PCOS compared to control groups.

According to genome studies (GWAS), FSHB gene on chromosome 11p14.1 represents the PCOS susceptibility focus in women (1). Genetic variations in FSHB affect male reproductive function. In fact, polymorphisms of the FSHB promoter have been associated with lower sperm count, higher LH, lower FSH and lower testicular volume (3,4).

In the light of this information, in this study, it was planned to evaluate the comparison of semen analysis results of male patients with a first-degree relative diagnosed with PCOS with the control group.

Connect with a study center

  • Etlik Zübeyde Hanım

    Ankara, 06000
    Turkey

    Site Not Available

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