Next Generation Rocklatan

Stage 1 Key Inclusion Criteria;

• Diagnosis of OAG or OHT in both eyes.

• High unmedicated IOP measurements in the study eye as specified in the protocol.

• Corrected visual acuity equal to or better than +1.0 logMAR (Snellen equivalentequal to or better than 20/200) in the study eye.

• Other protocol-specified inclusion criteria may apply.

Stage 2 Key Inclusion Criteria:

• Diagnosis of OAG or OHT in both eyes.

• High unmedicated IOP measurements in the study eye as specified in the protocol.

• Corrected visual acuity equal to or better than +0.7 logMAR (Snellen equivalentequal to or better than 20/100) in the study eye.

• Other protocol-specified inclusion criteria may apply.

Stage 1 and Stage 2 Key Exclusion Criteria:

• Current use of more than 2 ocular hypotensive medications within 30 days (eithereye).

• Intraocular pressure greater than 36 millimeters mercury (mmHg) at Screening.

• Glaucoma other than OAG.

• Previous glaucoma surgery.

• Any abnormality preventing reliable measurements.

• Unable to demonstrate proper eyedrop instillation.

• Other protocol-specified exclusion criteria may apply.