INSPIRE: a Multi-Cancer Early Detection Study

Inclusion Criteria for Case Arm Participants:

• 40-75 years old

• Clinically and/or pathologically diagnosed cancer

• No prior or undergoing any systemic or local antitumor therapy, including but not limited to surgical resection, radiochemotherapy, endocrinotherapy, targeted therapy, immunotherapy, interventional therapy, etc.

• Able to provide a written informed consent and willing to comply with all part of the protocol procedures

Exclusion Criteria for Case Arm Participants:

• Pregnancy or lactating women

• Known prior or current diagnosis of other types of malignancies comorbidities

• Have participated in an "interventional" clinical trial within the past 30 days and have taken the experimental drug;

• Recipients of organ transplant or prior bone marrow transplant or stem cell transplant

• Recipients of blood transfusion within 30 days prior to screen

• Recipients of therapy in past 14 days prior to screen, including oral or IV antibiotics, glucocorticoid, azacitidine, decitabine, procainamide, hydrazine, arsenic trioxide

• Failure to collect blood on time according to plan

• The blood sample does not meet the requirements

Inclusion Criteria for Control Arm Participants:

• 40-75 years old

• Without confirmed cancer diagnosis

• Able to provide a written informed consent and willing to comply with all part of the protocol procedures

Exclusion Criteria for Control Arm Participants:

• Pregnancy or lactating women

• No previous history of malignancy in other sites

• Recipients of organ transplant or prior bone marrow transplant or stem cell transplant

• Recipients of blood transfusion within 30 days prior to screen

• Recipients of therapy in the past 14 days prior to screen, including oral or IV antibiotics, glucocorticoid, azacitidine, decitabine, procainamide, hydrazine, arsenic trioxide

• Unsuitable for this trial determined by the researchers