Optimizing Bronchopulmonary Cancer Screening

Last updated: January 30, 2025
Sponsor: Institut Curie
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

Chest CTscan and follow-up

Screening

Inclusion

Clinical Study ID

NCT06439901
IC 2023-11
  • Ages 50-74
  • All Genders

Study Summary

The aim of this study is to evaluate the feasibility of performing a first screening for bronchopulmonary cancer by thoracic scanner in a French cohort within a dedicated, effective and structured network in the pilot centers participating in the study.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Participant aged 50 to 74.

  • Resident in the Île-de-France region.

  • Active smoker or quit smoker for 10 years or less:

  1. more than 10 cigarettes a day for more than 30 years,

  2. more than 15 cigarettes a day for more than 25 years.

  • The participant has been informed and has signed the consent form.

  • Social Security System affiliation.

  • Willingness to participate in a smoking cessation program, if currently smoking.

Exclusion

Exclusion Criteria:

  • Active cancer or a history of cancer in remission for less than 5 years (exceptbasal cell carcinoma of th skin or epithelioma in situ of the uterine cervix).

  • Presence of symptoms suggestive of bronchopulmonary cancer. Participants with thesesymptoms require immediate diagnostic investigations and are therefore not eligiblefor screening.

  • Weight >= 140 kg.

  • Severe comorbidity contraindicating therapeutic options or invasive thoracicdiagnostic investigations.

  • Inability to climb two flights of stairs without stopping.

  • A thoracic CTscan performed within the previous year.

  • Persons deprived of liberty or under guardianship.

  • Impossibility to undergo the medical monitoring of the trial for geographical,social or psychological reasons.

Study Design

Total Participants: 500
Treatment Group(s): 4
Primary Treatment: Chest CTscan and follow-up
Phase:
Study Start date:
January 17, 2025
Estimated Completion Date:
January 17, 2033

Study Description

The organization of bronchopulmonary cancer screening in the Ile de France region, within the Mutualists and its affiliated health centers, is based on a clear, simple and functional process:

  • Definition of eligibility criteria for screening, based on those of the NELSON study,

  • Referral and consultation by a health center physician trained in these criteria,

  • Referral and performance of a chest Computer Tomography Scanner (CTscan) according to the same recommendations,

  • Structured centralized reading and interpretation of CTscan images,

  • Referral to a multidisciplinary team (CITT), if bronchopulmonary cancer is suspected,

  • Referral to a tobacco unit in a health center for smokers who have not stopped smoking,

  • Organization of follow-up and continuation of the screening program.

Connect with a study center

  • Centre CTPS Bobigny Bondy

    Bobigny, 93000
    France

    Site Not Available

  • Centre Municipal de Santé Simone Veil

    Issy-les-Moulineaux, 92160
    France

    Site Not Available

  • Centre Municipal de Santé Jacqueline Akoun-Cornet

    Malakoff, 92240
    France

    Site Not Available

  • Centre Municipal de Santé Maurice Ténine

    Malakoff, 92240
    France

    Site Not Available

  • Centre de Santé MGEN

    Paris, 75738
    France

    Site Not Available

  • Centre de Santé Square de la Mutualité

    Paris, 75005
    France

    Active - Recruiting

  • Institut Curie

    Paris, 75248
    France

    Site Not Available

  • Institut Mutualiste Montsouris

    Paris, 75674
    France

    Site Not Available

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.