Single-center Study of Gustation in Idiopathic Parkinson's Disease and Lewy Body Disease Using Gustatory Evoked Potential Analysis

Last updated: June 6, 2024
Sponsor: Centre Hospitalier Universitaire Dijon
Overall Status: Active - Recruiting

Phase

N/A

Condition

Parkinson's Disease

Lewy Body Dementia

Treatment

Nutritional assessment

Fasting blood test

Neurocognitive assessment

Clinical Study ID

NCT06439355
SCHNEIDER J'InvEST-I 2023
  • Ages > 18
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The aim of the PI-PEG study is to explore the taste functions of the following 3 groups of participants:

  • healthy volunteers

  • patients with early Parkinson's disease

  • patients with incipient Lewy body disease.

To this end, the results obtained from taste evoked potentials in each of the 3 groups of participants will be compared with each other and with different nutritional, motor and cognitive data.

This study could reveal a difference in cortical processing of gustatory sensory information between patients who have had idiopathic Parkinson's disease progressing for 3 years or less, and patients who have had Lewy body disease progressing for 3 years or less. Indeed, a modification of taste evoked potentials (in terms of latencies) proportional to the degree of cerebral degeneration could be observed.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Healthy volunteers:

  • Person who has given written consent

  • Adult

  • Enrolled in the national register of healthy volunteers

  • Fasting > 2 hours before PEG measurement

  • Body Mass Index (BMI) < 30 kg/m².

  • No cognitive complaints and normal neurological assessment

Patients with idiopathic Parkinson's disease:

  • Person who has given written consent

  • Adult

  • Fasting > 2 hours before PEG measurement

  • Body Mass Index (BMI) < 30 kg/m².

  • Diagnostic criteria for established or probable IPD

Patients with Lewy body disease:

  • Person who has given written consent

  • Adult

  • Fasting > 2 hours prior to PEG measurement

  • Body Mass Index (BMI) < 30 kg/m².

  • Diagnostic criteria for probable or possible LBD

Exclusion

Exclusion Criteria:

  • Non-affiliated to national health insurance

  • Person under legal protection (curatorship, guardianship)

  • Person subject to a court order

  • Pregnant, parturient or breast-feeding women

  • Major unable to give consent

  • MMSE score < 15 and/or MoCA < 10

  • Known infection with COVID-19 in the 6 months prior to inclusion

  • Active smoker (> 4 cigarettes per day on a regular basis)

  • Subject with pacemaker (contraindication for bioelectrical impedancemetry)

  • Diabetic (type 1 or type 2)

  • Taking medication (in progress at the time of the study) that interferes withgustation

Study Design

Total Participants: 66
Treatment Group(s): 6
Primary Treatment: Nutritional assessment
Phase:
Study Start date:
May 27, 2024
Estimated Completion Date:
May 31, 2026

Connect with a study center

  • Chu Dijon Bourgogne

    Dijon,
    France

    Active - Recruiting

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