A Study of Brepocitinib in Adults With Active, Non-Infectious, Non-Anterior Uveitis

Inclusion Criteria:

• Adult subjects (18-75 years old)

• Diagnosis of non-infectious uveitis (intermediate uveitis, posterior uveitis, orpanuveitis)

• Active uveitic disease in at least 1 eye

• Weight > 40 kg with a body mass index ≤ 40 kg/m2

Exclusion Criteria:

Has confirmed or suspected current diagnosis of infectious uveitis History of or have:

1. Lymphoproliferative disorder

2. active malignancy

3. cancer within 5 years prior to screening (exceptions for basal cell carcinoma,squamous cell carcinoma, ductal carcinoma in situ of the breast, carcinoma in situof the uterine cervix, or thyroid carcinoma.)

4. thrombosis orand cerebrovascularardiovascular ischemic event disease within the last 12 months

5. a high risk for herpes zoster reactivation

6. active or recent infections