Phase
Condition
Chronic Lymphocytic Leukemia
Lymphoproliferative Disorders
Leukemia
Treatment
Venetoclax
Acalabrutinib
Obinutuzumab
Clinical Study ID
Ages > 18 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Diagnosis of documented, previously untreated, chronic lymphocytic leukemia (CLL)requiring treatment according to the 2018 international workshop on chroniclymphocytic leukemia (iwCLL) criteria and have a life expectancy of > 6 months.
Previously untreated small lymphocytic lymphoma (SLL) meeting the 2018 iwCLLcriteria for treatment will also be equally considered as CLL for eligibility,screening, treatment and evaluation.
Eastern Cooperative Oncology Group (ECOG) performance status <= 2.
Adequate marrow function independent of growth factor or transfusion support within 2 weeks of screening, unless cytopenia is due to marrow involvement of CLL as listedin the protocol.
Creatinine clearance (CrCl) >= 30 mL/min using the Cockcroft-Gault formula areeligible for inclusion.
Exclusion
Exclusion Criteria:
- Active/uncontrolled infection, no Richter's transformation, no active immune thrombocytopenia.
Study Design
Connect with a study center
Calvary Mater Newcastle /ID# 267408
Waratah, New South Wales 2298
AustraliaSite Not Available
Calvary Mater Newcastle /ID# 267408
Waratah 10103871, New South Wales 2155400 2298
AustraliaActive - Recruiting
Townsville University Hospital /ID# 266954
Townsville, Queensland 4814
AustraliaSite Not Available
Townsville University Hospital /ID# 266954
Townsville 2146142, Queensland 2152274 4814
AustraliaActive - Recruiting
St Vincent's Hospital - Melbourne /ID# 270027
Fitzroy, Victoria 3065
AustraliaSite Not Available
St Vincent's Hospital - Melbourne /ID# 270027
Fitzroy 2166584, Victoria 2145234 3065
AustraliaActive - Recruiting
Royal Perth Hospital /ID# 266906
Perth, Western Australia 6000
AustraliaSite Not Available
Royal Perth Hospital /ID# 266906
Perth 2063523, Western Australia 2058645 6000
AustraliaActive - Recruiting
Centre Hospitalier Universitaire de Saint Étienne - Hôpital Nord /ID# 266319
St-Priest-en-Jarez, Loire 42270
FranceActive - Recruiting
CHR Metz-Thionville - Hôpital de Mercy /ID# 266852
Ars Laquenexy, Moselle 57530
FranceSite Not Available
CHR Metz-Thionville - Hôpital de Mercy /ID# 266852
Ars-Laquenexy 3036715, Moselle 57530
FranceActive - Recruiting
Hopitaux Universitaires Henri Mondor - Hopital Henri Mondor /ID# 266270
Creteil, Paris 94010
FranceSite Not Available
Hopitaux Universitaires Henri Mondor - Hopital Henri Mondor /ID# 266270
Créteil 3022530, Paris 94010
FranceActive - Recruiting
Hopitaux Universitaires Paris Centre-Hopital Cochin /ID# 267438
Paris 2988507, Paris 75679
FranceActive - Recruiting
Hopitaux Universitaires Paris Centre-Hopital Cochin /ID# 267438
Paris CEDEX 14, Paris 75679
FranceSite Not Available
Centre Hospitalier Universitaire de Saint Etienne - Hopital Nord /ID# 266319
St-Priest-en-Jarez, Pays de la Loire Region 2988289 42270
FranceActive - Recruiting
Centre Antoine-Lacassagne /ID# 266894
Nice, Provence-Alpes-Cote-d Azur 06189
FranceSite Not Available
Centre Antoine-Lacassagne /ID# 266894
Nice 2990440, Provence-Alpes-Côte d'Azur Region 2985244 06189
FranceActive - Recruiting
Centre Hospitalier de la Côte Basque /ID# 266847
Bayonne, Pyrenees-Atlantiques 64109
FranceSite Not Available
Centre Hospitalier de la Côte Basque /ID# 266847
Bayonne 3034475, Pyrenees-Atlantiques 64109
FranceActive - Recruiting
Centre Hospitalier Métropole Savoie - Site Hôpital de Chambéry /ID# 266854
Chambery CEDEX, Savoie 73007
FranceSite Not Available
Centre Hospitalier Métropole Savoie - Site Hôpital de Chambéry /ID# 266854
Chambéry 3027422, Savoie 73007
FranceActive - Recruiting
CHU d'Amiens-Picardie - Hôpital Sud /ID# 266849
Amiens 3037854, Somme 80054
FranceActive - Recruiting
CHU d'Amiens-Picardie - Hôpital Sud /ID# 266849
Amiens CEDEX 1, Somme 80054
FranceSite Not Available
Centre Hospitalier d Argenteuil Victor Dupouy /ID# 266322
Argenteuil 3037044, Île-de-France Region 3012874 95107
FranceActive - Recruiting
Centre Hospitalier d'Argenteuil Victor Dupouy /ID# 266322
Argenteuil, 95107
FranceSite Not Available
Centre Hospitalier Régional d'Orléans - Hôpital de la Source /ID# 266272
Orléans, 45067
FranceSite Not Available
Centre Hospitalier Régional d'Orléans - Hôpital de la Source /ID# 266272
Orléans 2989317, 45067
FranceActive - Recruiting
Olympion General Clinic /ID# 266819
Patras, Achaia 25443
GreeceSite Not Available
Olympion General Clinic /ID# 266819
Pátrai 255683, Achaia 25443
GreeceActive - Recruiting
Evangelismos Hospital /ID# 266815
Athens 264371, Attica 6692632 10676
GreeceActive - Recruiting
General Hospital of Athens Laiko /ID# 266813
Athens 264371, Attica 6692632 11527
GreeceActive - Recruiting
University General Hospital Attikon /ID# 266814
Athens 264371, Attica 6692632 12462
GreeceActive - Recruiting
Evangelismos Hospital /ID# 266815
Athens, Attiki 10676
GreeceActive - Recruiting
General Hospital of Athens Laiko /ID# 266813
Athens, Attiki 11527
GreeceSite Not Available
University General Hospital Attikon /ID# 266814
Athens, Attiki 12462
GreeceActive - Recruiting
University General Hospital of Alexandroupoli /ID# 266816
Alexandroupoli, Evros 68100
GreeceSite Not Available
University General Hospital of Alexandroupoli /ID# 266816
Alexandroupoli 736928, Evros 68100
GreeceActive - Recruiting
Pan American Center for Oncology Trials /ID# 266243
Rio Piedras, 00935
Puerto RicoSite Not Available
Pan American Center for Oncology Trials /ID# 266243
Rio Piedras 4829037, 00935
Puerto RicoActive - Recruiting
Clinical Hospital Center - Bežanijska Kosa /ID# 266567
Belgrade, Beograd 11080
SerbiaActive - Recruiting
Clinical Hospital Center Zvezdara /ID# 266560
Belgrade, Beograd 11000
SerbiaSite Not Available
University Clinical Center Serbia /ID# 266579
Belgrade, Beograd 11000
SerbiaActive - Recruiting
Clinical Hospital Center - Bežanijska Kosa /ID# 266567
Belgrade 792680, Beograd 11080
SerbiaActive - Recruiting
Clinical Hospital Center Zvezdara /ID# 266560
Belgrade 792680, Beograd 11000
SerbiaActive - Recruiting
University Clinical Center Serbia /ID# 266579
Belgrade 792680, Beograd 11000
SerbiaActive - Recruiting
University Clinical Center Nis /ID# 266580
Niš, Nisavski Okrug 18300
SerbiaSite Not Available
University Clinical Center Nis /ID# 266580
Niš 787657, Nisavski Okrug 18300
SerbiaActive - Recruiting
University Clinical Center Kragujevac /ID# 266568
Kragujevac, Sumadijski Okrug 34000
SerbiaSite Not Available
University Clinical Center Kragujevac /ID# 266568
Kragujevac 789128, Sumadijski Okrug 34000
SerbiaActive - Recruiting
Institute for Oncology of Vojvodina /ID# 266556
Sremska Kamenica, Vojvodina 21208
SerbiaSite Not Available
Institute for Oncology of Vojvodina /ID# 266556
Kamenitz 3190104, Vojvodina 784272 21208
SerbiaActive - Recruiting
University Clinical Center Vojvodina /ID# 266674
Novi Sad, 21000
SerbiaSite Not Available
University Clinical Center Vojvodina /ID# 266674
Novi Sad 3194360, 21000
SerbiaActive - Recruiting
Complejo Hospitalario Universitario de Santiago (CHUS) /ID# 267164
Santiago de Compostela, A Coruna 15706
SpainSite Not Available
Complejo Hospitalario Universitario de Santiago (CHUS) /ID# 267164
Santiago de Compostela 3109642, A Coruna 15706
SpainActive - Recruiting
Hospital Universitario Puerta de Hierro - Majadahonda /ID# 266967
Majadahonda, Madrid 28222
SpainSite Not Available
Hospital Universitario Puerta de Hierro - Majadahonda /ID# 266967
Majadahonda 3117667, Madrid 3117732 28222
SpainActive - Recruiting
Clinica Universidad de Navarra - Pamplona /ID# 267762
Pamplona, Navarra 31008
SpainSite Not Available
Clinica Universidad de Navarra - Pamplona /ID# 267762
Pamplona 3114472, Navarre 3115609 31008
SpainActive - Recruiting
CLINICA UNIVERSIDAD DE NAVARRA-Madrid /ID# 266969
Madrid, 28027
SpainSite Not Available
Hospital MD Anderson Cancer Center Madrid /ID# 267167
Madrid, 28033
SpainActive - Recruiting
CLINICA UNIVERSIDAD DE NAVARRA-Madrid /ID# 266969
Madrid 3117735, 28027
SpainActive - Recruiting
Hospital MD Anderson Cancer Center Madrid /ID# 267167
Madrid 3117735, 28033
SpainActive - Recruiting
Hospital Universitario Virgen del Rocio /ID# 266968
Sevilla, 41013
SpainSite Not Available
Hospital Universitario Virgen del Rocio /ID# 266968
Seville 2510911, 41013
SpainActive - Recruiting
Kaohsiung Chang Gung Memorial Hospital /ID# 267046
Kaohsiung City, Kaohsiung 833
TaiwanSite Not Available
Kaohsiung Chang Gung Memorial Hospital /ID# 267046
Kaohsiung City 1673820, Kaohsiung 7280289 833
TaiwanActive - Recruiting
National Taiwan University Hospital /ID# 267017
Taipei City, Taipei 7280290 100
TaiwanActive - Recruiting
China Medical University Hospital /ID# 267018
Taichung, 404
TaiwanSite Not Available
China Medical University Hospital /ID# 267018
Taichung 1668399, 404
TaiwanActive - Recruiting
Linkou Chang Gung Memorial Hospital /ID# 267045
Taoyuan 6696918, 333
TaiwanActive - Recruiting
Linkou Chang Gung Memorial Hospital /ID# 267045
Taoyuan City, 333
TaiwanSite Not Available
Nottingham City Hospital /ID# 266991
Nottingham, Nottinghamshire NG5 1PB
United KingdomSite Not Available
Nottingham City Hospital /ID# 266991
Nottingham 2641170, Nottinghamshire NG5 1PB
United KingdomActive - Recruiting
Arizona Oncology - Tucson - Rudasill /ID# 267552
Tucson, Arizona 85704
United StatesActive - Recruiting
Southern VA Health Care System /ID# 266254
Tucson, Arizona 85723
United StatesSite Not Available
Arizona Oncology - Tucson - Rudasill /ID# 267552
Tucson 5318313, Arizona 5551752 85704
United StatesActive - Recruiting
Southern VA Health Care System /ID# 266254
Tucson 5318313, Arizona 5551752 85723
United StatesActive - Recruiting
UCSF FRESNO/Community Cancer Institute /ID# 270874
Clovis, California 93611
United StatesSite Not Available
Valkyrie Clinical Trials /ID# 268151
Los Angeles, California 90067
United StatesSite Not Available
UCSF FRESNO/Community Cancer Institute /ID# 270874
Clovis 5338122, California 5332921 93611
United StatesActive - Recruiting
Valkyrie Clinical Trials /ID# 268151
Los Angeles 5368361, California 5332921 90067
United StatesActive - Recruiting
Rocky Mountain Cancer Centers - Aurora /ID# 267549
Aurora, Colorado 80012
United StatesSite Not Available
Rocky Mountain Cancer Centers - Aurora /ID# 267549
Aurora 5412347, Colorado 5417618 80012
United StatesActive - Recruiting
Yale University School of Medicine /ID# 266224
New Haven, Connecticut 06510
United StatesSite Not Available
Yale University School of Medicine /ID# 266224
New Haven 4839366, Connecticut 4831725 06510
United StatesActive - Recruiting
Malcolm Randall V.A. Medical Center /ID# 267825
Gainesville, Florida 32608
United StatesSite Not Available
Cancer Specialists of North Florida - Jacksonville - AC Skinner Parkway /ID# 266713
Jacksonville, Florida 32256
United StatesSite Not Available
Mid Florida Hematology And Oncology Center /ID# 269159
Orange City, Florida 32763
United StatesSite Not Available
Comprehensive Hematology Oncology /ID# 267644
Saint Petersburg, Florida 33709
United StatesSite Not Available
Malcolm Randall V.A. Medical Center /ID# 267825
Gainesville 4156404, Florida 4155751 32608
United StatesActive - Recruiting
Cancer Specialists of North Florida - Jacksonville - AC Skinner Parkway /ID# 266713
Jacksonville 4160021, Florida 4155751 32256
United StatesActive - Recruiting
Mid Florida Hematology And Oncology Center /ID# 269159
Orange City 4167055, Florida 4155751 32763
United StatesActive - Recruiting
Comprehensive Hematology Oncology /ID# 267644
St. Petersburg 4171563, Florida 4155751 33709
United StatesActive - Recruiting
Springfield Clinic /ID# 270145
Springfield, Illinois 62702-3749
United StatesSite Not Available
Springfield Clinic - First /ID# 270145
Springfield 4250542, Illinois 4896861 62702
United StatesActive - Recruiting
Northwest Cancer Center - Dyer Clinic /ID# 268478
Dyer, Indiana 46311
United StatesSite Not Available
Northwest Cancer Center - Dyer Clinic /ID# 268478
Dyer 4919820, Indiana 4921868 46311
United StatesActive - Recruiting
Mission Cancer and Blood /ID# 267206
Des Moines, Iowa 50309
United StatesActive - Recruiting
University of Iowa Health Care /ID# 267206
Des Moines, Iowa 50314-3017
United StatesSite Not Available
University of Iowa Health Care /ID# 267206
Des Moines 4853828, Iowa 4862182 50314-3017
United StatesActive - Recruiting
Willis-Knighton Medical Center /ID# 270569
Shreveport, Louisiana 71103
United StatesSite Not Available
Willis-Knighton Medical Center /ID# 270569
Shreveport 4341513, Louisiana 4331987 71103
United StatesActive - Recruiting
American Oncology Partners of Maryland /ID# 266445
Bethesda, Maryland 20817
United StatesActive - Recruiting
Center for Cancer and Blood Disorders-American Oncology Partners of Maryland /ID# 266445
Bethesda, Maryland 20817
United StatesSite Not Available
Maryland Oncology Hematology - Silver Spring /ID# 267557
Silver Spring, Maryland 20904
United StatesSite Not Available
Center for Cancer and Blood Disorders-American Oncology Partners of Maryland /ID# 266445
Bethesda 4348599, Maryland 4361885 20817
United StatesActive - Recruiting
Maryland Oncology Hematology - Silver Spring /ID# 267557
Silver Spring 4369596, Maryland 4361885 20904
United StatesActive - Recruiting
UMass Memorial Medical Center /ID# 270023
Worcester, Massachusetts 01605
United StatesSite Not Available
UMass Memorial Medical Center /ID# 270023
Worcester 4956184, Massachusetts 6254926 01605
United StatesActive - Recruiting
Saint Luke's Hospital of Kansas City /ID# 267270
Kansas City, Missouri 64111
United StatesSite Not Available
Saint Luke's Hospital of Kansas City /ID# 267270
Kansas City 4393217, Missouri 4398678 64111
United StatesActive - Recruiting
Icahn School of Medicine at Mount Sinai /ID# 266328
New York, New York 10029
United StatesSite Not Available
Icahn School of Medicine at Mount Sinai /ID# 266328
New York 5128581, New York 5128638 10029
United StatesActive - Recruiting
Atrium Health /ID# 267219
Charlotte, North Carolina 28204-2963
United StatesSite Not Available
Atrium Health Wake Forest Baptist Medical Center /ID# 273142
Winston-Salem, North Carolina 27157
United StatesSite Not Available
Atrium Health /ID# 267219
Charlotte 4460243, North Carolina 4482348 28204-2963
United StatesActive - Recruiting
Atrium Health Wake Forest Baptist Medical Center /ID# 273142
Winston-Salem 4499612, North Carolina 4482348 27157
United StatesActive - Recruiting
Cleveland Clinic Main Campus /ID# 271292
Cleveland, Ohio 44195
United StatesSite Not Available
Cleveland Clinic Main Campus /ID# 271292
Cleveland 5150529, Ohio 5165418 44195
United StatesActive - Recruiting
Oklahoma Cancer Specialists and Research Institute /ID# 267643
Tulsa, Oklahoma 74146
United StatesSite Not Available
Oklahoma Cancer Specialists and Research Institute /ID# 267643
Tulsa 4553433, Oklahoma 4544379 74146
United StatesActive - Recruiting
Willamette Valley Cancer Institute and Research Center /ID# 266326
Eugene, Oregon 97401
United StatesSite Not Available
Willamette Valley Cancer Institute and Research Center /ID# 266326
Eugene 5725846, Oregon 5744337 97401
United StatesActive - Recruiting
Lifespan Cancer Institute - Providence /ID# 266550
Providence, Rhode Island 02903
United StatesSite Not Available
Lifespan Cancer Institute - Providence /ID# 266550
Providence 5224151, Rhode Island 5224323 02903
United StatesActive - Recruiting
Texas Oncology - Austin Midtown /ID# 268152
Austin, Texas 78705
United StatesSite Not Available
University of Texas - Southwestern Medical Center /ID# 266528
Dallas, Texas 75235
United StatesSite Not Available
Texas Oncology - Austin Midtown /ID# 268152
Austin 4671654, Texas 4736286 78705
United StatesActive - Recruiting
University of Texas - Southwestern Medical Center /ID# 266528
Dallas 4684888, Texas 4736286 75235
United StatesActive - Recruiting
Virginia Cancer Specialists - Gainesville /ID# 268155
Gainesville, Virginia 20155-3257
United StatesActive - Recruiting
Virginia Cancer Specialists - Gainesville /ID# 268155
Gainesville 4760363, Virginia 6254928 20155-3257
United StatesActive - Recruiting
Vista Oncology - East Olympia /ID# 267337
Olympia, Washington 98506
United StatesSite Not Available
Northwest Medical Specialties Tacoma /ID# 266327
Tacoma, Washington 98405
United StatesSite Not Available
Vista Oncology - East Olympia /ID# 267337
Olympia 5805687, Washington 5815135 98506
United StatesActive - Recruiting
Northwest Medical Specialties Tacoma /ID# 266327
Tacoma 5812944, Washington 5815135 98405
United StatesActive - Recruiting
West Virginia University School of Medicine /ID# 267645
Morgantown, West Virginia 26506
United StatesSite Not Available
West Virginia University School of Medicine /ID# 267645
Morgantown 4815352, West Virginia 4826850 26506
United StatesActive - Recruiting
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