Mechanical Thrombectomy of Acute Ischemic Stroke Anterior Circulation Distal Vessel Occlusion

Last updated: May 22, 2024
Sponsor: Assiut University
Overall Status: Active - Not Recruiting

Phase

N/A

Condition

Blood Clots

Occlusions

Cerebral Ischemia

Treatment

an array of devices are used in thrombectomy. These include guide catheters, stent-retrievers, microcatheters, aspiration catheters, and aspiration pump systems

Clinical Study ID

NCT06427187
Mechanical throbectomy
  • Ages 18-80
  • All Genders

Study Summary

Ischemic stroke continues to be of the leading causes of disability and death. Distal vessel occlusion one of most presenting and disabling varieties of ischemic stroke. Distal vessel occlusion stroke is a type of ischemic stroke that affects the small arteries in the brain, usually beyond the M2 segment of the middle cerebral artery. These strokes can cause various neurological symptoms depending on the location and size of the occluded vessel and the extent of the brain tissue damage

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • a. Inclusion criteria:
  1. Diagnosis of an acute ischemic stroke due to an occlusion of the anteriorcerebral artery (ACA) in the A1-A3 segment 2. Diagnosis of an acute ischemicstroke due to an occlusion of the middle cerebral artery in the distal M2segment or the M3 segment.

Exclusion

Exclusion Criteria:

  1. Posterior circulation small vessel occlusion

  2. Tandem lesions with occlusion of the ipsilateral ICA were excluded.

Study Design

Total Participants: 30
Treatment Group(s): 1
Primary Treatment: an array of devices are used in thrombectomy. These include guide catheters, stent-retrievers, microcatheters, aspiration catheters, and aspiration pump systems
Phase:
Study Start date:
June 01, 2024
Estimated Completion Date:
July 01, 2027

Study Description

DMVOs are defined by the Distal Thrombectomy Summit Group consensus statement as thromboembolic occlusion of the anterior cerebral artery, M2-M4 middle cerebral artery (MCA), posterior cerebral artery (PCA), posterior inferior cerebellar artery, anterior inferior cerebellar artery or superior cerebellar artery. It is estimated that 25-40% of all AIS is due to DMVO.Though distal vessel occlusion associated with poor disabling comorbidities'.With different aetiology weather primary Embolic from (heart, carotid or aorta),thrombotic (atherosclerotic, hypertension or Diabetes ,smoking &hyperlipidaemia) or Secondary distal vessel occlusion that occurs as a complication of a proximal large vessel occlusion, either spontaneously or after treatment with intravenous thrombolysis or endovascular thrombectomy. This can be due to thrombus fragmentation and migration or incomplete reperfusion of the affected vascular territory . Endovascular thrombectomy is well established as a highly effective treatment for acute ischemic stroke (AIS) due to proximal, large vessel occlusions (PLVOs). Recent advances in stent retriever and aspiration catheter technology are more promising results to reach more distal vessels, with a good outcome. However, MT in M2 emerging with different technique using stent Retriever or aspiration or both nowadays, evidence of other MT in distal vessel occlusion is poor.