Exploring the Relationship Between Heart Rate Variability (HRV), Training Load, and Exercise Performance

Last updated: May 24, 2024
Sponsor: PepsiCo Global R&D
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

Force plate assessment

Whoop wrist band

Clinical Study ID

NCT06425939
PEP-2401
  • Ages 25-50
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Heart rate variability (HRV) is a measure of the variation in time between each heartbeat.

It is an indirect and ubiquitous biomarker of performance readiness and recovery measured by most consumer-grade wearable fitness trackers. However, there is little documented on the relationship between HRV, training load, and performance measures in the Real-World.

Whoop wrist-worn activity trackers have been validated against the gold-standard Electrocardiography (ECG) for HRV and HR measurements. Whoop leverages photoplethysmography (PPG) technology to continuously track (HR, HRV, respiratory rate, energy expenditure) and provides, daily, individual insights, trends, and coaching to improve strain, sleep, and recovery. Research has demonstrated that heart rate variability (HRV) guided training may be more optimal compared to predetermined training for aerobic exercise improvements.

The purpose of this study is to assess the feasibility of providing personalized training recommendations based on HRV measured by a consumer-grade wearable (Whoop) in a real-world setting to better understand the HRV relationship with performance.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Actively participating in resistance training 2-4 times per week.

  2. Age 21-50 years, male and female.

  3. Subject is willing to refrain from vigorous exercise (light physical activity only) 24 hours prior to visit(s).

  4. Subject is willing to avoid alcohol consumption 24 hours prior to visit(s).

  5. Subject is willing to provide consent.

  6. Subject is able to continuously wear a wrist-worn device, including during sleep,except when submerged underwater (i.e., swimming, bathing).

Exclusion

Exclusion Criteria:

  1. Individual has a condition the Investigator believes would interfere with hisability to provide informed consent, comply with the project/study protocol, whichmight confound the interpretation of the project/study results or put the person atundue risk.

  2. Those with a medical history that would interfere with the results of this study.

  3. Under the care of a physician.

  4. Skin sensitivities.

  5. Sleep disorders.

  6. Using prescription medications that would impact sleep.

  7. If female, you are not pregnant, planning to get pregnant or currently breastfeeding.

  8. Smoker.

  9. Not able to wear wrist-worn device continuously.

  10. Lack of proficiency in English.

  11. Lack of proficiency or access to the internet and email address.

  12. Participation in another clinical trial within the past 30 days.

  13. Subject is employed by, or has a parent, guardian, or other immediate family memberemployed by a company that manufactures any products that compete with any Gatoradeproduct. If subject is unsure if a company would be considered a competitor toGatorade, they will be asked to please let the study investigator know the name ofthe other company and the nature of their relationship to that company before theysign the informed consent.

Study Design

Total Participants: 50
Treatment Group(s): 2
Primary Treatment: Force plate assessment
Phase:
Study Start date:
May 08, 2024
Estimated Completion Date:
September 30, 2024

Study Description

The purpose of this study is to determine if Training Intensity (%HRmax in min.) during Low HRV periods acutely (below HRV baseline next day and consecutive days) and chronically (weeks below previous weeks HRV baseline) will have a negative relationship with Post-Test Performance Metrics as measured by Force Plates, which could lead to personalized training recommendations using HRV. The Investigators conducted a pilot study using Whoop devices to monitor 50 subjects for 3 months and observed that individuals had High Training Load (above their baseline) on Low HRV days (below their baseline) on over 200 days. The Investigators hypothesize seeing similar High Training Load on Low HRV days during this study and would like to understand that relationship with Performance

Primary objective: To determine if Training Intensity (%HRmax in min.) during Low HRV periods acutely (below HRV baseline next day and consecutive days) and chronically (weeks below previous weeks HRV baseline) will have a negative relationship with Post-Test Performance Metrics as measured by Force Plates.

Secondary Objective : Measure and determine if subjective journal entries (mood, anxiety, recovery, etc.) are related to HRV, RHR, Sleep Quantity, and Sleep Efficiency.

Connect with a study center

  • PepsiCo R&D, Gatorade Sports Science Institute

    Chicago, Illinois 60607
    United States

    Active - Recruiting

  • PepsiCo R&D, Gatorade Sports Science Institute

    Frisco, Texas 75034
    United States

    Active - Recruiting

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