Dynamic Whole-body PET/CT Imaging in Clinical Oncology

Last updated: May 16, 2024
Sponsor: Valentina Garibotto
Overall Status: Active - Recruiting

Phase

N/A

Condition

Cancer

Treatment

PET/CT with FDG or FES

Clinical Study ID

NCT06424873
2023-02102
  • Ages > 18
  • All Genders

Study Summary

The goal of this clinical trial is to to achieve robust quantitative whole- body parametric imaging in clinically feasible scan times in patient with oncologic pathology .

The main question[s] it aims to answer are:

  • [question 1]

  • [question 2] Participants will [describe the main tasks participants will be asked to do, treatments they'll be given and use bullets if it is more than 2 items].

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Patients clinically indicated for whole-body PET evaluation.

  2. Patient must agree to lie still in the camera.

  3. Patient must be able to comply with study procedures.

  4. Patient must be able to provide informed consent.

Exclusion

Exclusion Criteria:

  1. Patients < 18 years of age.

  2. Pregnant women are excluded.

Study Design

Total Participants: 60
Treatment Group(s): 1
Primary Treatment: PET/CT with FDG or FES
Phase:
Study Start date:
April 01, 2024
Estimated Completion Date:
December 31, 2025

Study Description

Whole body hybrid PET/CT imaging, making use of the standardized uptake value (SUV), is well established in clinical setting for diagnosis and staging, treatment response monitoring and radiation therapy treatment planning of a wide range of oncologic malignancies. However, the SUV metric derived from static PET data does not capture the dynamics of the PET probe biodistribution in the body.

The present work proposes to fill in this notable gap: namely to merge whole-body and dynamic PET/CT imaging, to achieve robust quantitative whole- body parametric imaging in clinically feasible scan times. Our proposed approach has the potential to significantly enhance diagnostic, prognostic and treatment response monitoring capabilities of PET/CT and to fundamentally alter routine clinical practice.

Connect with a study center

  • Geneva University Hospitals

    Geneva, 1205
    Switzerland

    Active - Recruiting

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