Prebiotics and the Management of Hyperuricemia

Inclusion Criteria:

• Local residents aged between 18-80 years old;

• Stable weight (<5% weight change over the past 3 months);

• Fsating uric acid > 420 umol/L for male and > 360 umol/L for female on twodifferent days;

• Not taking uric acid lowering drugs or have stopped taking uric acid loweringdrugs for over 4 weeks at the time of recruitment;

• Absence of any diet or medication that might interfere with uric acidmetabolims or gut microbiota, especially antibiotics, prebiotics or probioticsat the least 4 weeks before recruitment

Exclusion Criteria:

• Acute illness or evidence of any acute or chronic inflammatroy of infectivediseases;

• Participation in regular diet program more than 2 times per week in the lastest 3 months prior to recruitment;

• Mental illness rendering them unable to understand the nature, scope, andpossible consequences of the study;

• Women of childbearing age who are pregant, breast-feeding or preparing forpregnancy; patients who had surgey within the past 6 months or planned surgeryduring the trial period.