Effect of TCI Propofol on Liver Transplant (TCI) Propofol on Intra-operative Usage of Vasopressors in Liver Transplant Recipients.

Last updated: May 13, 2024
Sponsor: Institute of Liver and Biliary Sciences, India
Overall Status: Active - Recruiting

Phase

2/3

Condition

N/A

Treatment

Inhalational isoflurane

Target control infusion propofol

Clinical Study ID

NCT06418893
IEC/2023/100/MA05
  • Ages 18-99
  • All Genders

Study Summary

Both isoflurane and propofol are being used to give anaesthesia for living donor liver transplant in our institute. Propofol when compared to isoflurane has advantages like early awakening from anaesthesia, reduced nausea, vomiting in the postoperative period. Propofol also has antioxidant properties. Because of its antioxidant properties propofol may have a protective effect against oxidative stress and ischemia reperfusion injury in major organs during liver transplant surgery. However, there are no studies showing the effect of isoflurane and propofol on Intraoperative hemodynamics and postoperative liver and kidney functions.Thus, we are conducting this study to know the effect of these agents on intraoperative hemodynamics and postoperative liver and kidney function.

Eligibility Criteria

Inclusion

Inclusion Criteria:-Above 18 years of age who will undergo living donor liver transplant

Exclusion

  • Exclusion Criteria: Refusal to consent

  • Acute liver failure, Acute on chronic liver failure

  • Allergic to propofol or any component of propofol

  • Patients with pre existing cardiac dysfunction and cardiomyopathy

  • Patients with pre existing renal dysfunction/ deranged RFTs preoperatively

Study Design

Total Participants: 60
Treatment Group(s): 2
Primary Treatment: Inhalational isoflurane
Phase: 2/3
Study Start date:
August 01, 2023
Estimated Completion Date:
October 31, 2024

Connect with a study center

  • Institute of liver and biliary sciences

    Delhi, 110070
    India

    Active - Recruiting

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