Daratumumab, Bortezomib, Cyclophosphamide, and Dexamethasone Therapy for Patients with MIDD

Inclusion Criteria:

1. Diagnosis of monoclonal immunoglobulin deposition disease without anti-plasma celltreatment

2. ECOG 0,1,2

3. Neu≥ 1.010^9/L, HGB ≥70g/L, PLT ≥ 5010^9/L.

4. Total bilirubin (TBil) ≤3×upper limit of normal (ULN); aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤3.0×ULN;

5. Informed consent explained to, understood by and signed by the patient.

Exclusion Criteria:

1. Prior therapy for MIDD, with the exception of equal or less than 160 mgdexamethasone (or equivalent corticosteroid)

2. Fulfill with the criteria of active multiple myeloma or active lymphoplasmacyticlymphoma.

3. Presence of other tumors which is/are in advanced malignant stage and has/havesystemic metastasis;

4. Severe or persistent infection that cannot be effectively controlled;

5. Presence of severe autoimmune diseases or immunodeficiency disease;

6. Patients with active hepatitis B or hepatitis C ([HBVDNA+] or [HCVRNA+]);

7. Patients with HIV infection or syphilis infection;

8. Any situations that the researchers believe will increase the risks for the subjector affect the results of the study.