The Safety and Effectiveness of NEPA in Preventing Postoperative Nausea and Vomiting After General Anesthesia Gastrointestinal Cancer Surgery: A Single-Center Retrospective Study

Inclusion Criteria:

1. Male or female, aged 18-65 years old; 2. The subjects were diagnosed withliver, gallbladder, and pancreatic diseases through histology or cytology andunderwent elective surgical treatment, including but not limited topancreaticoduodenectomy, liver resection, bile duct stone removal, etc., andreceived treatment with Netopitam Palonosetron capsules; 3. The subject is notin lactation period; 4. When screening female patients with potentialpregnancy, it is necessary to confirm that the pregnancy test must be negative;
2. The subjects voluntarily and strictly comply with the research protocolrequirements and sign a written informed consent form.

Exclusion Criteria:

1. Serious liver and kidney dysfunction, cardiopulmonary dysfunction, or otherserious diseases have not received standardized treatment; 2) Having a seriousmental illness in the past; 3) Take antiemetics or antidepressants within 48hours before surgery; 4) Patients receiving systemic glucocorticoid treatmentwithin 4 weeks prior to surgery; 5) Take NK1 receptor antagonists or anyinvestigational drugs within 4 weeks prior to the start of the experiment; 6)Use CYP3A4 inducer within 4 weeks prior to surgery, and CYP3A4 substrate orpotent, moderate CYP3A4 inhibitor within 1 week; 7) Pregnant or lactatingwomen, patients with fertility who are unwilling or unable to take effectivecontraceptive measures; 8) Drug and/or alcohol abuse; 9) Hypocalcemia or anyother condition that may cause vomiting; 10) The subject has an allergicreaction to Netopitam Palonosetron capsules or any of their excipients; 11)Participate in another clinical study within 30 days prior to baseline visit,using any exploratory drugs or devices; Allow participation in observationalresearch; 12) Researchers assess other situations that may affect the progressof clinical research and the determination of research results.