Multicenter Prospective Cohort Study of Twin Maternal-Child Dyads in China

Last updated: May 9, 2024
Sponsor: Peking University Third Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Pregnancy Complications

Treatment

N/A

Clinical Study ID

NCT06414655
ChiTwiMC
  • Ages 18-45
  • Female
  • Accepts Healthy Volunteers

Study Summary

Multicenter Prospective Cohort Study of Twin Maternal-Child Dyads in China (ChiTwiMC) is supported by National Key Research and Development Program of China - Reproductive Health and Women's and Children's Health Protection Project. This project is funded by the Ministry of Science and Technology of China under grant number 2023YFC2705900. The ChiTwiMC cohort is led by Professor Wei Yuan from the Department of Gynecology and Obstetrics at Peking University Third Hospital.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Twin pregnancies

  • Female aged between 18-45 years

  • Gestational age is less than 14 weeks

  • Planning to receive prenatal healthcare and delivery service at the study hospital

  • Signing informed concent and willing to participate

Exclusion

Exclusion Criteria:

  • Women with mental disorders or serious maternal illness that is not eligible toparticipate

  • Inability to provide informed consent

  • Pregnant women not registered in our hospital

Study Design

Total Participants: 2000
Study Start date:
March 01, 2024
Estimated Completion Date:
November 30, 2026

Study Description

The ChiTwiMC Cohort focusing on the serious complications of twin pregnancy, establish a multicenter large prospective mother-child cohort of twin pregnancy covering pregnancy→neonatal period→early childhood, and a multi-variety, multi-stage biobank for the study of adverse outcomes of twin pregnancy. The ChiTwiMC Cohort is planning to recruit 2000 pregnant women aged 18-45 years from 9 large obstetrical center of major University-affiliated Hospitals across China, between December 2023 and May 2026. All women will be enrolled prior to 14 wks of gestation, pregnancy was followed up at 22-28 wks, 30-38 wks of gestation, delivery, postpartum 42 days, 6 months, 12 months. Data including demographics, medical history, reproductive history, clinical diagnosis, treatment information, and pregnancy and birth outcomes will be collected via electronic data capture system. Track the outcome of severe maternal-fetal complications and early neonatal outcomes of twins, and collect biological samples, including peripheral venous blood, hair and cervicovaginal secretions from pregnant women, placenta tissue, amniotic fluid and unbilical cord blood at delivery, meconium and hair from newborns, buccal mucosa from infants and peripheral venous blood from the husband.

Connect with a study center

  • The First Affiliated Hospital of Anhui Medical University

    Hefei, Anhui 230001
    China

    Active - Recruiting

  • Peking University

    Peking, Beijing 10091
    China

    Active - Recruiting

  • Peking University Third Hospital

    Peking, Beijing 100191
    China

    Active - Recruiting

  • Chongqing Medical University

    Chongqing, Chongqing 400010
    China

    Active - Recruiting

  • First Affiliated Hospital, Sun Yat-Sen University

    Guangzhou, Guangdong 510000
    China

    Active - Recruiting

  • Shengjing Hospital

    Shenyang, Liaoning 110000
    China

    Active - Recruiting

  • Shandong Provincial Hospital

    Jinan, Shandong 250021
    China

    Active - Recruiting

  • The Second Hospital of Shandong University

    Jinan, Shandong 250033
    China

    Active - Recruiting

  • International Peace Maternity and Child Health Hospital

    Shanghai, Shanghai 200030
    China

    Active - Recruiting

  • Shanghai First Maternity and Infant Hospital

    Shanghai, Shanghai 201204
    China

    Active - Recruiting

  • Nankai University

    Tianjin, Tianjin 300071
    China

    Active - Recruiting

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