Evaluation of 3D Surface Scanning for Virtual-CT Based Radiation Therapy Treatment Planning

Last updated: March 6, 2025
Sponsor: Mayo Clinic
Overall Status: Active - Recruiting

Phase

N/A

Condition

Neoplasms

Treatment

Three-Dimensional Imaging

Electronic Health Record Review

Clinical Study ID

NCT06409000
19-012790
NCI-2022-09578
19-012790
ROA1971
  • Ages > 18
  • All Genders

Study Summary

This study evaluates if three dimensional (3D) surface images can be used instead of the standard computed tomography (CT) scans for treatment planning in electron radiation therapy. 3D scanning has previously been used by several groups to design patient-specific devices to be 3D printed, and as has shown excellent agreement with CT obtained surfaces. Using 3D surface imaging instead of x-ray based CT, benefits include: no ionizing radiation used to produce images, shorter time between patient consultation and treatment, and ability to produce and evaluate patient-specific devices for electron therapy earlier in the treatment planning process. This study may help researchers learn how 3D surface scanning may be used to produce a virtual CT image of patient surfaces, and accurately replace traditional planning CT for treatment planning of electron based radiation therapy.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Adults (18 years old or older)

  • Capable of consent

  • Receiving electron therapy and a planning CT scan

  • Consent to two 3D surface scans of treatment area

Exclusion

Exclusion Criteria:

  • Pediatric patients

  • Mentally incapable of study consent

  • Receiving electron radiation for a breast cancer boost

  • Receiving electrons for total skin electron therapy

  • Patients with epilepsy or other seizure disorders

Study Design

Total Participants: 26
Treatment Group(s): 2
Primary Treatment: Three-Dimensional Imaging
Phase:
Study Start date:
January 19, 2021
Estimated Completion Date:
August 31, 2025

Study Description

PRIMARY OBJECTIVES:

I. Develop and benchmark the necessary software to convert a 3D scan to a virtual CT.

II. Compare the spatial accuracy of virtual CTs from 3D scans to the planning CT.

III. Compare radiation treatment plans based on the virtual CTs from aim 2 to treatment plans based on the actual planning CTs.

OUTLINE: This is an observational study.

Patients undergo 3D surface scans on study. Patient's medical records are also reviewed on study.

Connect with a study center

  • Mayo Clinic in Arizona

    Scottsdale, Arizona 85259
    United States

    Active - Recruiting

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.