Ultrasound Findings in Diabetic Pregnancies

Last updated: May 6, 2024
Sponsor: Eastern Virginia Medical School
Overall Status: Active - Recruiting

Phase

N/A

Condition

Diabetic Kidney Disease

Diabetic Foot Ulcers

Diabetic Retinopathy

Treatment

N/A

Clinical Study ID

NCT06407388
23-03-FB-0061
  • Ages 18-45
  • Female

Study Summary

The goal of our study is to identify ultrasonographic markers that can predict adverse neonatal outcomes. Specifically, we hypothesize that an increase in fetal liver volumes will increase transcutaneous bilirubin (TcB) in the newborn and thus jaundice requiring phototherapy. This information can be used in patient counseling and to guide future screening protocols for ultrasound in individuals with diabetes.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients who enter pregnancy with a diagnosis of type I or type II diabetes mellitus.
  • Pregnant women between the ages of 18-45
  • Live, singleton gestation
  • Understanding and ability to give informed consent

Exclusion

Exclusion Criteria:

  • Patient unwilling or unable to provide consent
  • Intrauterine fetal demise (no fetal heart beat identified and documented by twophysicians)
  • Age less than 18 years of age
  • Multifetal gestation
  • Chromosomal abnormality
  • Congenital infection (Toxoplasmosis, Cytomegalovirus, Rubella, Varicella Zoster,Parvovirus B19
  • Major fetal congenital malformations (such as: major congenital heart defect,omphalocele, open neural tube defect, etc)

Study Design

Total Participants: 156
Study Start date:
June 01, 2023
Estimated Completion Date:
June 01, 2025

Study Description

This is a single center, prospective case control study. Cases will be collected prospectively and control subjects will be data collected retrospectively from the reference population of the human placenta project (IRB #15-09-FB-0179). If patients agree to participate, one ultrasound will be performed at 30-34 weeks' gestation to look at the fetal parameters as described below. It is standard of care for all patients with pregestational diabetes to receive growth ultrasounds throughout their pregnancy. Patients who are diagnosed with pregestational diabetes at EVMS routinely undergo an ultrasound at 30-34 weeks' gestation. Therefore, ultrasound data will be collected during their scheduled 30-34 week ultrasound visit and no additional ultrasounds will need to be performed. At the time of enrollment, the PI or other study collaborator will ensure that the patient has previously had a detailed ultrasound evaluation (Code 76811). These patients will then be followed prospectively until delivery. The neonates of the study patients will be followed via chart review after delivery.

Connect with a study center

  • Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Eastern Virginia Medical School

    Norfolk, Virginia 23507
    United States

    Active - Recruiting

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.