Last updated: May 6, 2024
Sponsor: University of British Columbia
Overall Status: Active - Recruiting
Phase
N/A
Condition
Diabetes Prevention
Diabetes Mellitus, Type 2
Diabetes And Hypertension
Treatment
Placebo Exercise
Exercise Snacks
Clinical Study ID
NCT06407245
H24-03417
Ages 30-75 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
- Aged 30-75 years.
- Have physician-diagnosed type 2 diabetes.
- Physically inactive (performing <150 min moderate-to-vigorous physical activity perweek).
- Body mass index: 18.5-40 kg/m2.
- Taking ≤3 glucose-lowering medications (excluding insulin) and stable dose for > 6months.
- Taking ≤2 commonly prescribed cardiovascular medications (e.g., statins,antihypertensive).
- HbA1c ≤8.5%.
- Able to maintain current physical activity patterns during the study.
- Cleared to engage in physical activity using the Get Active Questionnaire and, ifapplicable, consultation with a health care provider or Qualified ExerciseProfessional.
- Access to a computer, tablet or smartphone for intervention delivery and tracking.
- Ability to read and write in English.
Exclusion
Exclusion Criteria:
- Chronic musculoskeletal condition or recent (within 2 years) cardiovascular eventpreventing participation in exercise.
- Lack of internet access.
- Angina upon exertion assessed by the Rose Angina Questionnaire.
- Prescribed beta-blockers that can compromise the validity of heart rate measurements.during the submaximal exercise test.
- Have uncontrolled high blood pressure (hypertension; ≥ 160/90 mmHg) or an atypicalblood pressure or pulse rate at rest or during exercise as determined by a physician.
- Have a scheduled surgical procedure within the next 3-4 months that would preventexercise participation.
- Currently diagnosed with a cardiac or pulmonary disease (e.g., angina, arrythmia,exercise-induced bronchospasm) that would prevent exercise participation.
- Have a psychiatric disorder that could prevent you from completing the studyprocedures or visits.
- Have donated more than 0.5 L of blood within the last 4 weeks.
- Currently following an extreme diet (e.g., very low carbohydrate/calorie, ketogenic)or taking dietary/nutritional supplements that impact glucose control (e.g., exogenousketones).
- Currently have diabetic ulcers, peripheral vascular disease, or diabetic neuropathythat will prevent participation in exercise.
- Currently participating in another clinical trial that interferes with the studyprocedures.
- Currently on dialysis.
- Currently pregnant or planning on becoming pregnant during the intervention (i.e.,within the next 4 months).
- Have had an episode of severe hypoglycemia in the past 6 months (defined as havingneurological symptoms consistent with neuroglycopenia and required assistance intreatment by a second party).
Study Design
Total Participants: 80
Treatment Group(s): 2
Primary Treatment: Placebo Exercise
Phase:
Study Start date:
April 20, 2024
Estimated Completion Date:
July 19, 2025
Study Description
Connect with a study center
University of British Columbia Okanagan
Kelowna, British Columbia V1V 3G1
CanadaActive - Recruiting

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