Structural and Functional Networks in ALS: An Insight Into Pseudobulbar Affect

Last updated: January 28, 2025
Sponsor: Aalborg University Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Amyotrophic Lateral Sclerosis (Als)

Pseudobulbar Affect

Myasthenia Gravis (Chronic Weakness)

Treatment

Resting State Magnetoencephalography

Diffusion Kurtosis Imaging (DKI)

Clinical Study ID

NCT06396260
F2024-014
  • Ages 18-90
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The investigators aim to elucidate characteristics of structural and functional brain connectivity in patients with amyotrophic lateral sclerosis (ALS) and pseudobulbar affect (PBA) using diffusion kurtosis imaging (DKI) and magnetoencephalography (MEG).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Diagnosed with ALS in the last 6 months according to Gold Coast Criteria

Exclusion

Exclusion Criteria:

  • Lack of ability to answer survey through own ability or through a surrogate,for example by hand controlled, eye-controlled computer and/or tablet, orthrough telephone interview.

  • Lack of ability to cooperate.

  • Pregnancy

  • Drug addiction defined as the non-prescribed use of cannabis, opioids, or othernarcotics.

  • Alcohol addiction defined as over 21 units weekly.

  • Lesional neurological diseases, such as stroke, tumor or multiple sclerosis

  • Epilepsy

  • Neurodegenerative diseases other than ALS

  • Severe psychiatric disease such as major depression disorder, bipolar disease orschizophrenia

  • Contraindication for MRI and MEG scan according to hospital guidelines

  • Severe liver or kidney disease

  • Dysregulated heart disease

  • Ongoing treatment with any antidepressants or any antipsychotics at recruitment.

  • Diagnosed with frontotemporal dementia.

Study Design

Total Participants: 50
Treatment Group(s): 2
Primary Treatment: Resting State Magnetoencephalography
Phase:
Study Start date:
May 26, 2024
Estimated Completion Date:
December 31, 2026

Connect with a study center

  • Aalborg University hospital

    Aalborg, Northern Jutland 9500
    Denmark

    Active - Recruiting

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