Evaluation of the Efficacy and Safety of Fecal Microbiota Transplantation for Constipation in Parkinson's Disease

Inclusion Criteria:

1. Participants who fulfill Chinese diagnostic criteria for PD (2016 edition), aged 40-75 years;

2. PD Hoehn-Yahr stage 1-3

3. Participants who have at least 2 of the following symptoms in the past 3 months andthe symptoms have been present for at least 6 months: ① More than 25% of defecationsare laborious; ② More than 25% of defecations consist of hard or lumpy stools; ③More than 25% of defecations are accompanied by a sensation of incompleteevacuation; ④ More than 25% of defecations are accompanied by a sensation ofanorectal obstruction; ⑤ More than 25% of defecations require manual assistance; ⑥Less than 3 spontaneous bowel movements per week.

4. Have taken a stable dose of anti-Parkinson drugs, antidepressants and antipsychoticsfor at least 1 month;

5. Absence of red flags such as weight loss, hematochezia and exclusion of otherdiagnosis;

6. Have signed the informed consent and agree to participate in this study;

Exclusion Criteria:

1. Parkinsonism-plus syndrome;

2. Stroke, brain trauma or epilepsy;

3. Have undergone surgery intervention due to PD;

4. Pregnant, planning pregnancy or lactating;

5. Psychiatric disorder or unable to cooperate with treatment and follow-up visit;

6. Immunodeficiency or treatment with immune-modulating medication;

7. Have undergone any abdominal surgery, with the exception of appendectomy,cholecystectomy, caesarean section and hysterectomy;

8. Presence of uncontrolled diabetes, hypertension, thyroid disease or other systemicdisease;

9. Use of probiotics or antibiotics within 1 month prior to study entry;

10. Presence of severe diseases related to heart, brain, kidney and lung or concomitantmalignancies;