A Research Study to See How Well Different Doses of CagriSema Help People With Excess Body Weight Lose Weight

Last updated: May 3, 2026
Sponsor: Novo Nordisk A/S
Overall Status: Completed

Phase

3

Condition

Obesity

Diabetes Prevention

Treatment

Placebo

Cagrilintide

Semaglutide

Clinical Study ID

NCT06388187
NN9838-7749
2023-509273-24
U1111-1298-3451
  • Ages > 18
  • All Genders

Study Summary

This study will look at how well CagriSema helps people with excess body weight lose weight. CagriSema is a new medicine developed by Novo Nordisk that combines cagrilintide and semaglutide. CagriSema cannot yet be prescribed by doctors. In the study, participant will either get CagriSema or dummy medicine and which treatment participant get is decided by chance. The study will last for about 1½ years for each participant.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Male or female

  • Age above or equal to 18 years at the time of signing informed consent

  1. Body Mass index (BMI) greater than or equal to (≥) 30.0 kilogram per metersquare (kg/m^2) or

  2. BMI ≥27.0 kg/m2 with the presence of at least one obesity related complicationincluding, but not limited to hypertension, dyslipidaemia, obstructive sleepapnoea or cardiovascular disease

Exclusion

Exclusion Criteria:

  • Glycated haemoglobin (HbA1c) ≥6.5% (48 millimoles per mole [mmol/mol]) as measuredby the central laboratory at screening

  • History of type 1 or type 2 diabetes

Study Design

Total Participants: 300
Treatment Group(s): 3
Primary Treatment: Placebo
Phase: 3
Study Start date:
June 24, 2024
Estimated Completion Date:
April 22, 2026

Connect with a study center

  • Ocean West Research Clinic

    Surrey, British Columbia V3Z 2N6
    Canada

    Site Not Available

  • Ocean West Research Clinic

    Surrey 6159905, British Columbia 5909050 V3Z 2N6
    Canada

    Site Not Available

  • Nova Scotia Health Authority

    Halifax, Nova Scotia B3H 1V7
    Canada

    Site Not Available

  • Nova Scotia Health Authority

    Halifax 6324729, Nova Scotia 6091530 B3H 1V7
    Canada

    Site Not Available

  • Wharton Med Clin Trials

    Hamilton, Ontario L8L 5G8
    Canada

    Site Not Available

  • Wharton Medical Clinic Clinical Trials (Hamilton)

    Hamilton, Ontario L8L 5G8
    Canada

    Site Not Available

  • Wharton Med Clin Trials

    Hamilton 5969782, Ontario 6093943 L8L 5G8
    Canada

    Site Not Available

  • Hospices Civils de Lyon-Hopital Lyon Sud-1

    Pierre-Benite, 69310
    France

    Site Not Available

  • Hospices Civils de Lyon-Hopital Lyon Sud

    Pierre-Bénite, 69310
    France

    Site Not Available

  • Hospices Civils de Lyon-Hopital Lyon Sud-1

    Pierre-Bénite, 69310
    France

    Site Not Available

  • Hospices Civils de Lyon-Hopital Lyon Sud

    Pierre-Bénite 2987314, 69310
    France

    Site Not Available

  • Hospices Civils de Lyon-Hopital Lyon Sud-1

    Pierre-Bénite 2987314, 69310
    France

    Site Not Available

  • Centre Hospitalier Universitaire de Nantes-Hopital Nord Laennec-1

    Saint Herblain, 44800
    France

    Site Not Available

  • Centre Hospitalier Universitaire de Nantes-Hopital Nord Laennec

    Saint-Herblain, 44800
    France

    Site Not Available

  • Centre Hospitalier Universitaire de Nantes-Hopital Nord Laennec

    Saint-Herblain 2979590, 44800
    France

    Site Not Available

  • Centre Hospitalier Universitaire de Toulouse-Hopital Rangueil

    Toulouse, 31059
    France

    Site Not Available

  • Centre Hospitalier Universitaire de Toulouse-Hopital Rangueil

    Toulouse 2972315, 31059
    France

    Site Not Available

  • Centre Hospitalier Universitaire de Toulouse-Hopital Rangueil-1

    Toulouse Cedex 9, 31059
    France

    Site Not Available

  • InnoDiab Forschung GmbH

    Essen, 45136
    Germany

    Site Not Available

  • InnoDiab Forschung GmbH

    Essen 2928810, 45136
    Germany

    Site Not Available

  • Wendisch - Dahl Hamburg - DZHW

    Hamburg, 22607
    Germany

    Site Not Available

  • Wendisch/Dahl Hamburg

    Hamburg, 22607
    Germany

    Site Not Available

  • Wendisch - Dahl Hamburg - DZHW

    Hamburg 2911298, 22607
    Germany

    Site Not Available

  • AmBeNet GmbH

    Leipzig, 04107
    Germany

    Site Not Available

  • AmBeNet GmbH

    Leipzig 2879139, 04107
    Germany

    Site Not Available

  • Institut für Diabetesforschung GmbH Münster - Dr. med. Rose

    Münster, 48145
    Germany

    Site Not Available

  • Institut für Diabetesforschung GmbH Münster - Dr. med. Rose

    Münster 2867543, 48145
    Germany

    Site Not Available

  • Forschungszentrum Ruhr KliFoCenter GmbH, Dr. med. Kahrmann

    Witten, 58455
    Germany

    Site Not Available

  • Forschungszentrum Ruhr KliFoCenter GmbH, Kahrmann

    Witten, 58455
    Germany

    Site Not Available

  • Forschungszentrum Ruhr KliFoCenter GmbH, Kahrmann

    Witten 2807363, 58455
    Germany

    Site Not Available

  • The Health Centre

    Bradford-on-Avon, BA15 1DQ
    United Kingdom

    Site Not Available

  • The Health Centre

    Bradford-on-Avon 2654991, BA15 1DQ
    United Kingdom

    Site Not Available

  • Southmead Hospital

    Bristol, BS10 5NB
    United Kingdom

    Site Not Available

  • Southmead Hospital

    Bristol 2654675, BS10 5NB
    United Kingdom

    Site Not Available

  • Addenbrooke's Hospital_Cambridge

    Cambridge, CB2 0QQ
    United Kingdom

    Site Not Available

  • Addenbrooke's Hospital_Cambridge

    Cambridge 2653941, CB2 0QQ
    United Kingdom

    Site Not Available

  • University Hospital Coventry - WISDEM Centre

    Coventry, CV2 2DX
    United Kingdom

    Site Not Available

  • WISDEM Centre

    Coventry, CV2 2DX
    United Kingdom

    Site Not Available

  • University Hospital Coventry - WISDEM Centre

    Coventry 2652221, CV2 2DX
    United Kingdom

    Site Not Available

  • Staploe Medical Centre

    Soham, CB7 5JD
    United Kingdom

    Site Not Available

  • The Staploe Medical Centre

    Soham, CB7 5JD
    United Kingdom

    Site Not Available

  • Staploe Medical Centre

    Soham 2637554, CB7 5JD
    United Kingdom

    Site Not Available

  • Joint Clinical Research Facility - Swansea

    Swansea, SA2 8PP
    United Kingdom

    Site Not Available

  • Joint Clinical Research Facility - Swansea

    Swansea 2636432, SA2 8PP
    United Kingdom

    Site Not Available

  • Aurora FDRC Inc.

    Costa Mesa, California 92627
    United States

    Site Not Available

  • Aurora FDRC Inc.

    Costa Mesa 5339840, California 5332921 92627
    United States

    Site Not Available

  • Clinical Trial Res Assoc,Inc

    Plantation, Florida 33324
    United States

    Site Not Available

  • Clinical Trial Res Assoc,Inc

    Plantation 4168782, Florida 4155751 33324
    United States

    Site Not Available

  • Midwest Inst For Clin Res

    Indianapolis, Indiana 46260
    United States

    Site Not Available

  • Midwest Inst For Clin Res

    Indianapolis 4259418, Indiana 4921868 46260
    United States

    Site Not Available

  • Accellacare

    Wilmington, North Carolina 28401
    United States

    Site Not Available

  • Accellacare

    Wilmington 4499379, North Carolina 4482348 28401
    United States

    Site Not Available

  • Velocity Clinical Res-Dallas

    Dallas, Texas 75230
    United States

    Site Not Available

  • Velocity Clinical Res-Dallas

    Dallas 4684888, Texas 4736286 75230
    United States

    Site Not Available

  • Washington Cntr Weight Mgmt

    Arlington, Virginia 22206
    United States

    Site Not Available

  • Washington Cntr Weight Mgmt

    Arlington 4744709, Virginia 6254928 22206
    United States

    Site Not Available

  • Capital Clin Res Ctr,LLC

    Olympia, Washington 98502
    United States

    Site Not Available

  • Capital Clin Res Ctr,LLC

    Olympia 5805687, Washington 5815135 98502
    United States

    Site Not Available

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