The Acute Effect of "Exercise Snacks" on Glycemic Responses in Individuals With Type 2 Diabetes.

Last updated: May 6, 2024
Sponsor: University of British Columbia
Overall Status: Active - Recruiting

Phase

N/A

Condition

Diabetes Mellitus, Type 2

Diabetes Prevention

Diabetes And Hypertension

Treatment

Exercise snacks

Clinical Study ID

NCT06382246
H24-Acute-ExSnacks
  • Ages 30-75
  • All Genders

Study Summary

To conduct a randomized crossover trial to determine the acute impact of exercise snacks on glycemic control in physically inactive individuals living with type 2 diabetes using continuous glucose monitoring.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Aged 30-75 years old.
  • Have physician-diagnosed type 2 diabetes.
  • Currently participating in less than 150 minutes of moderate-to-vigorous intensityaerobic exercise per week.
  • Have a body mass index between 18.5 and 40 kg/m2.
  • Have had a stable medication dosage and no changes to the number of prescribedmedications for at least 6 months.
  • Able to maintain current medication doses during the study.
  • Able to maintain current physical activity patterns during the study.
  • HbA1c is less than or equal to 8.5%.
  • Have access to a computer, tablet, or smartphone for intervention delivery andtracking.
  • Can travel to McMaster University for in-person laboratory testing visits.
  • Can read, write, and understand English.
  • Anticipate having access to the internet for the duration of the intervention (i.e.,over the next 3-4 months).
  • Cleared for exercise participation based on the CSEP Get Active Questionnaire and theRose Angina Questionnaire.

Exclusion

Exclusion Criteria:

  • Taking 4 or more glucose-lowering medications.
  • Taking insulin.
  • Taking beta-blockers.
  • Taking 3 or more commonly prescribed medications for the prevention of cardiovasculardisease (e.g., statins, antihypertensives).
  • Have had an episode of severe hypoglycemia in the past 6 months (defined as havingneurological symptoms consistent with neuroglycopenia and required assistance intreatment by a second party).
  • Currently a cigarette smoker.
  • Have a chronic musculoskeletal condition that would prevent participation in exercise.
  • Have had a recent (within the last 2 years) cardiovascular event that preventsparticipation in exercise.
  • Experience angina upon exertion.
  • Have uncontrolled high blood pressure (hypertension) or an atypical blood pressure orpulse rate at rest or during exercise as determined by a physician.
  • Have a scheduled surgical procedure within the next 3-4 months that would preventexercise participation.
  • Currently diagnosed with a cardiac or pulmonary disease (e.g., angina, arrythmia,exercise-induced bronchospasm) that would prevent exercise participation.
  • Have a psychiatric disorder that could prevent you from completing the studyprocedures or visits.
  • Have donated more than 0.5 L of blood within the last 4 weeks.
  • Currently following an extreme diet (e.g., very low carbohydrate/calorie, ketogenic)or taking dietary/nutritional supplements that impact glucose control (e.g., exogenousketones).
  • Currently have diabetic ulcers, peripheral vascular disease, or diabetic neuropathythat will prevent participation in exercise.
  • Currently on dialysis.
  • Currently participating in another clinical trial that interferes with the studyprocedures.
  • Currently pregnant or planning on becoming pregnant during the intervention (i.e.,within the next 3-4 months).

Study Design

Total Participants: 30
Treatment Group(s): 1
Primary Treatment: Exercise snacks
Phase:
Study Start date:
April 20, 2024
Estimated Completion Date:
July 15, 2025

Study Description

Participants will perform two, 48-hour experimental conditions separated by 24 hours while wearing a continuous glucose monitor to measure glycemic responses. The order of the trials will be randomized for each participant. The two trials will include an exercise condition (EX) and a control, non-exercise condition (CON). During the EX trial, participants will perform four exercise snacks per day on two consecutive days (i.e., Monday and Tuesday). Each exercise snack will be 1-minute in duration and consist of bodyweight style exercise performed with vigorous effort. During the CON trial, participants will be asked to refrain from any structured exercise during two consecutive days (i.e., Thursday and Friday). All meals will be provided to participants during the two 48-hour trials and will be standardized for a given participant. There will be a one-day wash out period in between the completion of both trials for all participants.

Connect with a study center

  • University of British Columbia Okanagan

    Kelowna, British Columbia V1V 3G1
    Canada

    Active - Recruiting

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