Role of Calcium Chloride Injection in Alleviating Atrial Fibrillation Post CABG

Last updated: April 19, 2024
Sponsor: Helwan University
Overall Status: Active - Recruiting

Phase

3

Condition

Arrhythmia

Chest Pain

Cardiac Disease

Treatment

Sodium Chloride 0.9% Inj

Calcium Chloride

Clinical Study ID

NCT06378021
Calcium chloride in CABG
  • Ages 18-74
  • All Genders

Study Summary

This study hypothesize that injecting calcium chloride (CaCl2) into the major atrial ganglionated plexus (GPs) during on pump Coronary artery bypass graft (CABG) can reduce the incidence of Post operative Atrial fibrillation in the first 7 days after surgery.The study is designed to be prospective interventional study two armed RCT for on pump CABG patient.

The intervention arm will be injected with Calcium chloride in the four major atrial ganglionic plexus The control arm will be injected with sodium chloride to determine the effect of Calcium chloride on Post CABG Atrial fibrillation

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Patients more than 18 years old 2 ) patients undergoing On pump CABG

Exclusion

Exclusion Criteria:

  1. patients >75 years of age
  2. Patients with Pre operative Atrial fibrillation
  3. Patients with Significant valvular disease
  4. Ejection fraction <30% 6. Combined surgery of any kind 7. Congenital heart disease 8.Abnormal severe liver or kidney dysfunction. 9. Patients undergoing Off-pump CABG 10.Poorly controlled hyperthyroidism 11. Refusal to enrollment.

Study Design

Total Participants: 100
Treatment Group(s): 2
Primary Treatment: Sodium Chloride 0.9% Inj
Phase: 3
Study Start date:
March 14, 2024
Estimated Completion Date:
April 30, 2025

Study Description

This study hypothesize that injecting calcium chloride into the major atrial ganglionic plexus (GPs) during On pump Coronary artery bypass graft (CABG) can reduce the incidence of Post operative Atrial fibrillation by calcium-induced autonomic neurotoxicity, the incidence of Post operative Atrial fibrillation can be reduced by suppressing the function of the major atrial GPs and the surrounding neural network that play an important role in initiating Post operative Atrial fibrillation. The study is designed to be prospective interventional study two armed RCT for on pump CABG patient. The plan of work will include dividing the patients into 2 randomized control groups In the intervention group patients will be injected with 5% Calcium chloride in the 4 Major atrial ganglionic plexus The other arm will be Coronary artery bypass graft patients who will be injected with sodium chloride 0.9% to compare the two groups to evaluate to evaluate the effect of Calcium chloride in post CABG atrial fibrillation between the 2 arms of the study.

Connect with a study center

  • Ain shams university

    Cairo, Abassia Cairo 02
    Egypt

    Active - Recruiting

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