Study Evaluating the Safety and Efficacy of RAP-219 in Adult Participants With Refractory Focal Epilepsy

Inclusion Criteria:

• Medically refractory focal epilepsy with an implanted responsive neurostimulatordevice placed correctly in a seizure onset zone that meet several device-relatedcriteria and demonstrated history of compliance with interrogation of the RNS deviceand upload of data

• If currently treated with antiseizure medications, up to a maximum of 4 concomitantmediations are allowed

• At least 1 clinical seizure during the 8-week retrospective eligibility period

• Participants in otherwise good health as determined by the investigator

• Willing and able to adhere to all aspects of the protocol

• A demonstrated history of compliance with interrogation of the RNS device and uploadof data before screening

Exclusion Criteria:

• Participants with generalized onset seizures in the past 10 years

• History of status epilepticus while on antiseizure medications within 2 years ofscreening

• Individuals of reproductive potential who do not agree to simultaneously use twoeffective birth-control methods

• Participants who have had epilepsy surgery within the last 12 months beforescreening