Radicle GI Health 24: A Study of Health and Wellness Products on GI Health and Related Health Outcomes

Inclusion Criteria:

• Adults, at least 21 years of age at the time of electronic consent, inclusive of allethnicities, races, and gender identities. Assigned sex at birth will determinesex-specific recruitment and surveys (male vs female) employed, when needed

• Resides in the United States

• Endorses a desire for improved bowel habits, less bloating/indigestion, and/or fewerstomach aches/pains

• Has the opportunity for at least 20% improvement in their primary health outcome

• Expresses a willingness to take a study product and not know the product identity (active or placebo) until the end of the study

Exclusion Criteria:

• Report being pregnant, trying to become pregnant, or breastfeeding

• Unable to provide a valid US shipping address and mobile phone number

• Reports current enrollment in another clinical trial

• Reports being a heavy drinker (defined as drinking 3 or more alcoholic beverages perday)

• Unable to read and understand English

• Reports a current and/or recent (up to 3 months ago) major illness and/or surgerythat poses a known, significant safety risk.

• Reports a diagnosis of cardiac dysfunction, liver or kidney disease that presents aknown contraindication and/or a significant safety risk with any of the studyproduct ingredients. NYHA (New York Heart Association) Class Ill or IV congestiveheart failure, atrial fibrillation, uncontrolled arrhythmias, cirrhosis, end-stageliver disease, stage 3b or 4 chronic kidney disease, or kidney failure

• Reports taking medications that have a well-established moderate or severeinteraction, posing a substantial safety risk with any of the study productingredients. Anticoagulants, antihypertensives, anxiolytics, antidepressants,chemotherapy, immunotherapy, sedative hypnotics, seizure medications, medicationsthat warn against grapefruit consumption, corticosteroids at doses greater than 5 mgper day, diabetic medications, oral anti-infectives (antibiotics, antifungals,antivirals) to treat an acute infection, antipsychotics, MAOls (monoamine oxidaseinhibitors), or thyroid products

• Reports current use of the primary ingredient(s) and/or similar product(s) to theactive study product(s) that may limit the effects of the study product

• Lack of reliable daily access to the internet