Computerized Cognitive Behavioral Therapies for Suicide Prevention and Depression

Last updated: April 17, 2025
Sponsor: VA Eastern Colorado Health Care System
Overall Status: Active - Recruiting

Phase

2

Condition

Suicide

Depression

Treatment

Cognitive Behavioral Therapy

Clinical Study ID

NCT06375083
23-1231
  • Ages 18-65
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

This study plans to learn more about the use of one of two self-guided online cognitive behavioral therapy courses. One is focused on symptoms of depression and one is focused on history of suicidal thoughts and behaviors.

Eligibility Criteria

Inclusion

Cohort A - cCBT-SP Program

Inclusion Criteria:

  1. Veterans between the ages of 18 and 65

  2. Currently living in Colorado, New York, Montana, Texas, or Utah who have accessed VACare

  3. Recent suicidal ideation (past month; C-SSRS Screener -Yes to Item 2) and history oflifetime suicidal behavior (lifetime, C-SSRS Screener - Yes to Item 6)

  4. Reliable access to a computer/tablet and the internet

  5. Ability to provide informed consent

Exclusion

Exclusion Criteria:

  1. Active alcohol or substance use disorder, excluding Cannabis dependence, asdetermined by screening or electronic medical record

  2. Identification of active psychosis or bipolar disorder, as determined via screeningor electronic medical record

  3. Severe cognitive impairment, as determined by screening or electronic medical record

  4. Currently enrolled in/participating in another mental health-related interventionresearch study

Cohort B - cCBT-D Program

Inclusion Criteria:

  1. Veterans between the ages of 18 and 65

  2. Currently living in Colorado, New York, Montana, Texas, or Utah who have accessed VAcare

  3. Mild to moderate depressive symptoms, as determined by the PHQ-9, (score of 5-14)

  4. Reliable access to a computer/tablet and the internet

  5. Ability to provide informed consent

Exclusion Criteria:

  1. PHQ-9 score below 4 or 15 and above

  2. Active alcohol or substance use disorder, excluding Cannabis dependence, asdetermined by screening or electronic medical record

  3. Identification of active psychosis or bipolar disorder, as determined via screeningor electronic medical record

  4. Severe cognitive impairment, as determined by screening or electronic medical record

  5. Currently enrolled in/participating in other intervention research study

Study Design

Total Participants: 472
Treatment Group(s): 1
Primary Treatment: Cognitive Behavioral Therapy
Phase: 2
Study Start date:
March 20, 2024
Estimated Completion Date:
August 30, 2025

Study Description

Based on previous work with other computerized CBT (cCBT) interventions (e.g., cCBT-D), which has found that cCBT has similar effectiveness to traditional CBT, members of the team along with Veterans Health Administration (VHA) leaders have developed computerized cCBT-SP and cCBT-D courses that will be ready for safety, feasibility, and acceptability testing. If proven to be feasible, safe, and effective, these courses could be made available to all Veterans, at no cost to users.

Connect with a study center

  • Eastern Colorado Health Care System

    Aurora, Colorado 80045
    United States

    Active - Recruiting

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