A Study of Auxora in Patients With AKI and Injurious Lung "Crosstalk"

Inclusion Criteria:

1. The patient is ≥ 18 years of age.

2. The patient has developed Stage 2 or Stage 3 AKI.

3. The patient has a documented partial pressure of oxygen [Pa02]/fraction of inspiredoxygen [FiO2] (P/F) ≤ 300 in the prior 24 hours, either imputed from SpO2 orobtained from an arterial blood gas, that is not explained by cardiogenic pulmonaryedema or volume overload

4. The patient is being treated with either high flow nasal cannula with minimum flowrate ≥ 30 liters/min, or non-invasive mechanical ventilation, or invasive mechanicalventilation at time of randomization.

5. A female patient of childbearing potential who is sexually active with a malepartner is willing to practice acceptable methods of birth control for 30 days afterthe last dose of study drug.

6. A male patient who is sexually active with a female partner of childbearingpotential is willing to practice acceptable methods of birth control for 30 daysafter the last dose of study drug. A male patient must not donate sperm for 30 daysafter the last dose of study drug.

7. The patient is willing and able to, or has a legally authorized representative (LAR)who is willing and able to, provide informed consent to participate and to cooperatewith all aspects of the protocol.

Exclusion Criteria:

1. The patient has a do not intubate directive.

2. The patient has chronic lung disease that requires supplemental non-invasive oxygenas an outpatient or home mechanical ventilation. The use of non-invasive mechanicalventilation to treat obstructive sleep apnea is not an exclusion.

3. The patient has been hospitalized in the ICU for more than 10 days.

4. The patient has been receiving invasive mechanical ventilation for > 120 hours.

5. The patient is receiving extracorporeal membrane oxygen (ECMO).

6. The patient has started or is planned to start kidney replacement therapy (KRT)before randomization.

7. The patient has a serum triglyceride level ≥ 500 mg/dL.

8. The patient has a direct bilirubin level >3.0 mg/dL or both a direct bilirubin level ≥ 2.0 mg/dL and an international normalized ratio (INR) ≥ 1.7.

9. AKI is suspected to be secondary to: renal artery or renal vein thrombosis;hepato-renal syndrome; cholesterol emboli syndrome; acute glomerulonephritis;vasculitis; acute allergic interstitial nephritis; intrarenal or extrarenal urinarytract obstruction; use of immune checkpoint inhibitor.

10. The patient has a known history of an organ transplant.

11. The patient has a known history of HIV infection.

12. The patient has known history of hepatitis B infection.

13. The patient is currently receiving chemotherapy.

14. The patient is currently receiving immunosuppressive medications

15. The patient is known to be pregnant or is currently nursing.

16. The patient is allergic to eggs.

17. The patient is currently participating in another study of an investigational drug