Cold Saline Irrigation Before Endobronchial Biopsy

Last updated: February 10, 2025
Sponsor: TriHealth Inc.
Overall Status: Active - Enrolling

Phase

N/A

Condition

N/A

Treatment

Flush

Cold saline irrigation

Clinical Study ID

NCT06373224
23-037
  • Ages > 18
  • All Genders

Study Summary

Patients undergoing an endobronchial ultrasound and biopsy can experience bleeding during the biopsy. These biopsies are read in real time by pathologists who travel to the endoscopy unit during the procedure. Often, when this happens, the blood contaminates the pathology slides making the slide unreadable. This then requires more biopsies to be performed, thus prolonging the procedure, and increasing anesthesia time. One innovative way to reduce bleeding may be to irrigate the bronchial wall with cold saline, where the biopsy is to be taken, immediately before biopsy, thus causing vasoconstriction and possibly resulting in less blood contamination on the biopsy slides. The current study will evaluate this prophylactic irrigation with saline to control bleeding, thus resulting in a quicker diagnostic result of the biopsies.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Undergoing an endobronchial ultrasound and biopsy at Bethesda North Hospital

Exclusion

Exclusion Criteria:

  • Under 18 years old

  • Does not speak English

  • Unable to consent to involvement in the research study

  • Is pregnant

  • Has a bleeding disorder/diagnosis

  • Currently taking anticoagulant medications and not stopped for procedure

  • Documented low platelets (<100,000)

  • Had a biopsy taken immediately prior to the endobronchial ultrasound

Study Design

Total Participants: 120
Treatment Group(s): 2
Primary Treatment: Flush
Phase:
Study Start date:
December 01, 2023
Estimated Completion Date:
February 02, 2027

Connect with a study center

  • Bethesda North Hospital

    Cincinnati, Ohio 45242
    United States

    Site Not Available

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